Document Detail

Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouse.
MedLine Citation:
PMID:  21452206     Owner:  NLM     Status:  MEDLINE    
A subpopulation of retinal ganglion cells (RGCs) expresses the photopigment melanopsin, rendering these cells intrinsically photosensitive (ipRGCs). These cells are critical for competent circadian entrainment, pupillary light reflex, and other non-imaging-forming photic responses. Research has now demonstrated the presence of multiple subpopulations of ipRGC based on the dendritic stratification in the inner plexiform layer (IPL), those monostratified in the Off sublamina (M1), those monostratified in the On sublamina (M2,4,5), and those bistratified in both the On and the Off sublaminae (M3). Despite evidence that M1 and M2 cells are distinct subpopulations of ipRGC based on distinct morphological and physiological properties, the inclusion of M3 cells as a distinct subtype has remained controversial. Aside from the identification of M3 cells as a morphological subpopulation of ipRGC, to date there have been no functional descriptions of M3 cell physiology or synaptic inputs. Our data provide the first in-depth description of M3 cell structural and functional properties. We report that M3 cells form a morphologically heterogeneous population but one that is physiologically homogeneous with properties similar to those of M2 cells.
Tiffany M Schmidt; Paulo Kofuji
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  519     ISSN:  1096-9861     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-04-19     Completed Date:  2011-08-10     Revised Date:  2013-07-23    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1492-504     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley-Liss, Inc.
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA.
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MeSH Terms
Mice, Knockout
Patch-Clamp Techniques
Photic Stimulation
Retinal Ganglion Cells / classification,  cytology,  drug effects,  physiology*
Rod Opsins / genetics,  metabolism
Sodium Channel Blockers / pharmacology
Tetrodotoxin / pharmacology
Grant Support
R01EY012949/EY/NEI NIH HHS; R21 EY018885/EY/NEI NIH HHS; R21-EY018885/EY/NEI NIH HHS; T32 EY0707133/EY/NEI NIH HHS; T32 GM008471/GM/NIGMS NIH HHS
Reg. No./Substance:
0/Rod Opsins; 0/Sodium Channel Blockers; 0/melanopsin; 4368-28-9/Tetrodotoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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