Document Detail


Structure and function of active chromatin and DNase I Hypersensitive Sites.
MedLine Citation:
PMID:  21501387     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chromatin is by its very nature a repressive environment which restricts the recruitment of transcription factors and acts as a barrier to polymerases. Therefore, the complex process of gene activation must operate at two levels. In the first instance, localised chromatin decondensation and nucleosome displacement is required to make DNA accessible. Secondly, sequence-specific transcription factors need to recruit chromatin modifiers and remodelers to create a chromatin environment that permits the passage of polymerases. In this review I will discuss the chromatin structural changes that occur at active gene loci, and at regulatory elements that exist as DNase I Hypersensitive Sites.
Authors:
Peter N Cockerill
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-19
Journal Detail:
Title:  The FEBS journal     Volume:  -     ISSN:  1742-4658     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101229646     Medline TA:  FEBS J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Journal compilation © 2011 Federation of European Biochemical Societies.
Affiliation:
Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, St James's University Hospital, Leeds LS9 7TF, United Kingdom.
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