Document Detail


Structure and expression of the follicle-stimulating hormone receptor gene in a marsupial, Macropus eugenii.
MedLine Citation:
PMID:  12211057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Follicle stimulating hormone (FSH) is essential for folliculogenesis. The function of FSH is mediated through its receptor (FSHr) and modulation of the receptor is thought to be the mechanism by which the responsiveness of follicles to gonadotrophins is regulated. FSHr is alternatively spliced to produce several transcripts in all eutherian species studied. However, controversy exists over the significance of alternatively spliced transcripts. In this study, we cloned and characterised the tammar wallaby (Macropus eugenii) FSHr gene and examined its expression. Comparison of gene structure and function between marsupials and eutherians enables identification of conserved features that are likely to be of functional significance. Tammar FSHr shares 94% amino acid similarity with human FSHr and is expressed in both the adult testis and ovary suggesting a similar function for this gene in both marsupials and eutherians. Tammar FSHr undergoes alternate splicing to produce four transcripts consistent with the splice variants seen in eutherians. These results strongly suggest that alternate splicing is of functional significance in the ovary since it has remained a highly conserved character of this gene for over 100 million years of divergent evolution.
Authors:
D Mattiske; A J Pask; J M Shaw; G Shaw
Related Documents :
15226307 - Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spa...
20705037 - Antisense therapy corrects nonsense mutation by exon skipping.
24929817 - Survival, prophage induction, and invasive properties of lysogenic salmonella typhimuri...
14664827 - Distinct elements of the peripheral myelin protein 22 (pmp22) promoter regulate express...
18701917 - Prevention of interferon-stimulated gene expression using microrna-designed hairpins.
24095927 - Critical role of foxo3a in alcohol-induced autophagy and hepatotoxicity.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular reproduction and development     Volume:  63     ISSN:  1040-452X     ISO Abbreviation:  Mol. Reprod. Dev.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-04     Completed Date:  2003-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8903333     Medline TA:  Mol Reprod Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  24-31     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Affiliation:
Department of Zoology, University of Melbourne, Australia. d.mattiske@zoology.unimelb.edu.au
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Cloning, Molecular
DNA, Complementary / genetics
Female
Gene Expression Regulation
Genes
Humans
Macropodidae / genetics*
Male
Mammals / genetics
Molecular Sequence Data
Ovary / metabolism
RNA, Messenger / biosynthesis,  genetics
Receptors, FSH / biosynthesis,  genetics*
Reverse Transcriptase Polymerase Chain Reaction
Sequence Alignment
Sequence Homology, Amino Acid
Testis / metabolism
Chemical
Reg. No./Substance:
0/DNA, Complementary; 0/RNA, Messenger; 0/Receptors, FSH

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Toxicogenomic effects of neonatal exposure to diethylstilbestrol on mouse testicular gene expression...
Next Document:  Inheritance of resistance of bovine preimplantation embryos to heat shock: relative importance of th...