Document Detail


Structure and dynamics of primary hydration shell of phosphatidylcholine bilayers at subzero temperatures.
MedLine Citation:
PMID:  8968597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deuterium NMR relaxation and intensity measurements of the 2H-labeled H2O/dimyristoyl phosphatidylcholine bilayer were performed to understand the molecular origin of the freezing event of phospholipid headgroup and the structure and dynamics of unfrozen water molecules in the interbilayer space at subzero temperatures. The results suggest that about one to two water molecules associated with the phosphate group freeze during the freezing event of phospholipid headgroups, whereas about five to six waters near the trimethylammonium group behave as a water cluster and remain unfrozen at temperatures as low as -70 degrees C. In addition, temperature-dependent T1 and T2 relaxation times suggest that dynamic coupling occurs not only between the phosphate group and its bound water, but also between the methyl group and the adjacent water molecules. Based on these observations, the primary hydration shell of phosphatidylcholine headgroup at subzero temperatures is suggested to consist of two distinct regions: a clathrate-like water cluster, most likely a water pentamer, near the hydrophobic methyl group, and hydration water molecules associated with the phosphate group.
Authors:
C H Hsieh; W G Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biophysical journal     Volume:  71     ISSN:  0006-3495     ISO Abbreviation:  Biophys. J.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-04-07     Completed Date:  1997-04-07     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3278-87     Citation Subset:  IM    
Affiliation:
Department of Life Sciences, National Tsing Hua University, Hsinchu, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Deuterium
Dimyristoylphosphatidylcholine / chemistry*
Freezing
Kinetics
Lipid Bilayers / chemistry*
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Conformation
Phosphatidylcholines / chemistry*
Quaternary Ammonium Compounds
Thermodynamics
Chemical
Reg. No./Substance:
0/Lipid Bilayers; 0/Phosphatidylcholines; 0/Quaternary Ammonium Compounds; 13699-48-4/Dimyristoylphosphatidylcholine; 7782-39-0/Deuterium
Comments/Corrections

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