Document Detail

Structure of cymbidine A, a monomeric peptidoglycan-related compound with hypotensive and diuretic activities, isolated from a higher plant, Cymbidium goeringii (Orchidaceae).
MedLine Citation:
PMID:  17473468     Owner:  NLM     Status:  MEDLINE    
The structure of a new monomeric peptidoglycan-related compound with hypotensive and diuretic activities, cymbidine A (1) isolated from the orchid Cymbidium goeringii, was elucidated mainly by spectroscopic analysis. The structure of 1 was shown to involve four amino acids (D-alanin, meso-diaminopimelic acid, D-gultamic acid, and L-valine) and two amino sugars (N-acetylglucosamine and 1,6-anhydro-N-acetylmuramic acid). The sequence of the amino acids and amino sugars was determined by the analysis of 2D NMR data. The absolute stereochemistries of the three amino acids (D-Ala, D-Glu and L-Val) were determined by the modified Marfey's method, and the (6S,10R) configurations of meso-diaminopimelic acid in 1 were indicated on the basis of the CD analysis. The absolute stereochemistry of 1,6-anhydro-N-acetylmuramic acid was also determined by CD data.
Kinzo Watanabe; Rina Tanaka; Hitomi Sakurai; Kazuo Iguchi; Yasuji Yamada; Chau-Shin Hsu; Chiseko Sakuma; Hiroyuki Kikuchi; Humio Shibayama; Tadahide Kawai
Related Documents :
19839028 - Structure characterization of lipocyclopeptide antibiotics, aspartocins a, b & c, by es...
25026678 - Enhancement of insecticides against codling moth (lepidoptera: tortricidae) with l-aspa...
24816428 - Selective preparation of diamondoid phosphonates.
23670098 - Metabolomic study of the fever model induced by baker's yeast and the antipyretic effec...
24505438 - Rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spec...
9870908 - Lipid peroxidation of isolated chylomicrons and oxidative status in plasma after intake...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  55     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-02     Completed Date:  2007-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  780-3     Citation Subset:  IM    
School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan .
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antihypertensive Agents / isolation & purification*,  pharmacology*
Carbohydrate Sequence
Diuretics / isolation & purification*,  pharmacology*
Glycopeptides / isolation & purification*,  pharmacology*
Hypertension / chemically induced,  drug therapy,  physiopathology
Magnetic Resonance Spectroscopy
Molecular Conformation
Molecular Sequence Data
Orchidaceae / chemistry*
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectroscopy, Fourier Transform Infrared
Reg. No./Substance:
0/Antihypertensive Agents; 0/Diuretics; 0/Glycopeptides; 0/cymbidine A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Multistep, microwave assisted, solvent free synthesis and antibacterial activity of 6-substituted-2,...
Next Document:  Production of triterpene acids by cell suspension cultures of Olea europaea.