Document Detail


Structure of cymbidine A, a monomeric peptidoglycan-related compound with hypotensive and diuretic activities, isolated from a higher plant, Cymbidium goeringii (Orchidaceae).
MedLine Citation:
PMID:  17473468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The structure of a new monomeric peptidoglycan-related compound with hypotensive and diuretic activities, cymbidine A (1) isolated from the orchid Cymbidium goeringii, was elucidated mainly by spectroscopic analysis. The structure of 1 was shown to involve four amino acids (D-alanin, meso-diaminopimelic acid, D-gultamic acid, and L-valine) and two amino sugars (N-acetylglucosamine and 1,6-anhydro-N-acetylmuramic acid). The sequence of the amino acids and amino sugars was determined by the analysis of 2D NMR data. The absolute stereochemistries of the three amino acids (D-Ala, D-Glu and L-Val) were determined by the modified Marfey's method, and the (6S,10R) configurations of meso-diaminopimelic acid in 1 were indicated on the basis of the CD analysis. The absolute stereochemistry of 1,6-anhydro-N-acetylmuramic acid was also determined by CD data.
Authors:
Kinzo Watanabe; Rina Tanaka; Hitomi Sakurai; Kazuo Iguchi; Yasuji Yamada; Chau-Shin Hsu; Chiseko Sakuma; Hiroyuki Kikuchi; Humio Shibayama; Tadahide Kawai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  55     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-02     Completed Date:  2007-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  780-3     Citation Subset:  IM    
Affiliation:
School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan .
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / isolation & purification*,  pharmacology*
Carbohydrate Sequence
Diuretics / isolation & purification*,  pharmacology*
Glycopeptides / isolation & purification*,  pharmacology*
Hydrolysis
Hypertension / chemically induced,  drug therapy,  physiopathology
Magnetic Resonance Spectroscopy
Molecular Conformation
Molecular Sequence Data
Orchidaceae / chemistry*
Rats
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectroscopy, Fourier Transform Infrared
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Diuretics; 0/Glycopeptides; 0/cymbidine A

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