| Structure of cymbidine A, a monomeric peptidoglycan-related compound with hypotensive and diuretic activities, isolated from a higher plant, Cymbidium goeringii (Orchidaceae). | |
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MedLine Citation:
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PMID: 17473468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The structure of a new monomeric peptidoglycan-related compound with hypotensive and diuretic activities, cymbidine A (1) isolated from the orchid Cymbidium goeringii, was elucidated mainly by spectroscopic analysis. The structure of 1 was shown to involve four amino acids (D-alanin, meso-diaminopimelic acid, D-gultamic acid, and L-valine) and two amino sugars (N-acetylglucosamine and 1,6-anhydro-N-acetylmuramic acid). The sequence of the amino acids and amino sugars was determined by the analysis of 2D NMR data. The absolute stereochemistries of the three amino acids (D-Ala, D-Glu and L-Val) were determined by the modified Marfey's method, and the (6S,10R) configurations of meso-diaminopimelic acid in 1 were indicated on the basis of the CD analysis. The absolute stereochemistry of 1,6-anhydro-N-acetylmuramic acid was also determined by CD data. |
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Authors:
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Kinzo Watanabe; Rina Tanaka; Hitomi Sakurai; Kazuo Iguchi; Yasuji Yamada; Chau-Shin Hsu; Chiseko Sakuma; Hiroyuki Kikuchi; Humio Shibayama; Tadahide Kawai |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 55 ISSN: 0009-2363 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-02 Completed Date: 2007-07-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 780-3 Citation Subset: IM |
Affiliation:
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School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan . |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / isolation & purification*, pharmacology* Carbohydrate Sequence Diuretics / isolation & purification*, pharmacology* Glycopeptides / isolation & purification*, pharmacology* Hydrolysis Hypertension / chemically induced, drug therapy, physiopathology Magnetic Resonance Spectroscopy Molecular Conformation Molecular Sequence Data Orchidaceae / chemistry* Rats Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Infrared Spectroscopy, Fourier Transform Infrared |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Diuretics; 0/Glycopeptides; 0/cymbidine A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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