Document Detail

Structure and conformation of helical nucleic acids: analysis program (SCHNAaP).
MedLine Citation:
PMID:  9356255     Owner:  NLM     Status:  MEDLINE    
We present a new versatile program, SCHNAaP, for the analysis of double-helical nucleic acid structures. The program uses mathematically rigorous and fully reversible procedures for calculating the structural parameters: the Cambridge University Engineering Department Helix computation Scheme (CEHS) is used to determine the local helical parameters and an analogous procedure is used to determine the global helical parameters. These parameters form a complete set that conforms to the "Cambridge Accord" on definitions and nomenclature of nucleic acid structure parameters. In addition to the two standard Watson-Crick base-pairs, the program handles mismatched base-pairs and chemically modified bases. An analysis of the sugar-phosphate backbone conformation is included. Standardized base-stacking diagrams of each dinucleotide step with reference to the mid-step triad are generated. Structures are classified as one of the four polymorphic families, A/B, Z, W or R, although W- and R-DNA (two types of hypothetical structure) have yet to be observed experimentally.
X J Lu; M A El Hassan; C A Hunter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular biology     Volume:  273     ISSN:  0022-2836     ISO Abbreviation:  J. Mol. Biol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-01-20     Completed Date:  1998-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985088R     Medline TA:  J Mol Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  668-80     Citation Subset:  IM    
Copyright Information:
Copyright 1997 Academic Press Limited.
Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK.
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MeSH Terms
Base Composition
DNA / chemistry*,  classification
Mathematical Computing
Molecular Structure
Nucleic Acid Conformation*
Reg. No./Substance:

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