Document Detail


Structure and conformation of fourteen antibiotics of the quinoxaline group determined by 1H NMR.
MedLine Citation:
PMID:  7068517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nuclear magnetic resonance has been employed to characterize fourteen new antibiotics belonging to the quinoxaline group, produced by feeding aromatic acids to Streptomyces echinatus. Twelve of the antibiotics are the expected substituted quinomycins and adopt conformations very similar to that of echinomycin. This is discussed in relation to their different DNA-binding characteristics. The other two antibiotics are triostins, supporting the proposal that triostins serve as biosynthetic precursors of the quinomycins.
Authors:
M P Williamson; D Gauvreau; D H Williams; M J Waring
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  35     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-06-24     Completed Date:  1982-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  62-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents* / biosynthesis
Magnetic Resonance Spectroscopy / methods
Molecular Conformation
Quinoxalines
Streptomyces / metabolism
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Quinoxalines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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