| Structure and conformation of fourteen antibiotics of the quinoxaline group determined by 1H NMR. | |
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MedLine Citation:
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PMID: 7068517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nuclear magnetic resonance has been employed to characterize fourteen new antibiotics belonging to the quinoxaline group, produced by feeding aromatic acids to Streptomyces echinatus. Twelve of the antibiotics are the expected substituted quinomycins and adopt conformations very similar to that of echinomycin. This is discussed in relation to their different DNA-binding characteristics. The other two antibiotics are triostins, supporting the proposal that triostins serve as biosynthetic precursors of the quinomycins. |
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Authors:
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M P Williamson; D Gauvreau; D H Williams; M J Waring |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of antibiotics Volume: 35 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 1982 Jan |
Date Detail:
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Created Date: 1982-06-24 Completed Date: 1982-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 62-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents*
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biosynthesis Magnetic Resonance Spectroscopy / methods Molecular Conformation Quinoxalines Streptomyces / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Quinoxalines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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