Document Detail


Structure and chromosomal mapping of a highly polymorphic repetitive DNA sequence from the pseudoautosomal region of the mouse sex chromosomes.
MedLine Citation:
PMID:  1973377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pseudoautosomal region of the Mov15 mouse strain is marked by a Moloney murine leukemia provirus. The sequences flanking the Mov15 provirus were molecularly cloned and shown to consist of a tandemly repeated sequence of 31 nucleotides. Copy number variation of this repeat most likely accounts for the polymorphism in the mouse pseudoautosomal region detected with a probe from the flanking sequences. In situ hybridization to metaphase chromosomes showed heavy labeling of the pairing region of the X and Y chromosomes. The repetitive sequence was also found at the subtelomeric region of three autosomes. A similar level of amplification as the one seen on the sex chromosomes seems to be present on chromosomes 9 and 13. Lower copy number appear to be present on chromosome 4.
Authors:
K Harbers; U Francke; P Soriano; R Jaenisch; U Müller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cytogenetics and cell genetics     Volume:  53     ISSN:  0301-0171     ISO Abbreviation:  Cytogenet. Cell Genet.     Publication Date:  1990  
Date Detail:
Created Date:  1990-08-21     Completed Date:  1990-08-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367735     Medline TA:  Cytogenet Cell Genet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Affiliation:
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Universität Hamburg FRG.
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Blotting, Southern
DNA*
DNA Transposable Elements
Gene Frequency
Mice / genetics*
Mice, Transgenic
Molecular Sequence Data
Nucleic Acid Hybridization
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Repetitive Sequences, Nucleic Acid*
Restriction Mapping*
Sex Chromosomes / ultrastructure*
Grant Support
ID/Acronym/Agency:
5R 35CA 44339/CA/NCI NIH HHS; GM 26105/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/DNA Transposable Elements; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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