Document Detail

Structure activity relationships of stendomycin, a lipopeptide antibiotic from Streptomyces.
MedLine Citation:
PMID:  1406345     Owner:  NLM     Status:  MEDLINE    
A strain of Streptomyces which produced stendomycin, a lipopeptide antibiotic, was grown in culture media containing various amino acids as nitrogen substrates. The nature of the fatty acid component of stendomycin was dependent on the nature of the amino acid present in the medium, but this did not affect antibiotic activity. Modifications in the peptide moiety resulted in a loss of antifungal activity.
B Losilla; M T Pommier; N Bonnaveiro; A Cremieux; G Michel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microbios     Volume:  71     ISSN:  0026-2633     ISO Abbreviation:  Microbios     Publication Date:  1992  
Date Detail:
Created Date:  1992-11-23     Completed Date:  1992-11-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0207257     Medline TA:  Microbios     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  75-80     Citation Subset:  IM    
Laboratoire de Biochimie Microbienne, Université Claude Bernard, Lyon I, Villeurbanne, France.
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MeSH Terms
Amino Acids
Anti-Bacterial Agents*
Antifungal Agents / biosynthesis,  chemistry,  pharmacology*
Fatty Acids / analysis
Nitrogen / metabolism
Peptide Biosynthesis
Peptides / chemistry,  pharmacology*
Streptomyces / metabolism*
Structure-Activity Relationship
Reg. No./Substance:
0/Amino Acids; 0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Fatty Acids; 0/Lipids; 0/Peptides; 11006-78-3/stendomycin; 7727-37-9/Nitrogen

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