Document Detail

Structure-activity relationships of dihydrofolate reductase inhibitors.
MedLine Citation:
PMID:  8195829     Owner:  NLM     Status:  MEDLINE    
Structure-activity relationships of antibacterial dihydrofolate reductase inhibitors are reviewed. A short introduction is followed by a more detailed review of developments since 1980. The design of site directed inhibitors based on data from X-ray crystallographic, NMR spectroscopy and molecular graphic studies is discussed. The development of quantitative structure-activity relations is surveyed from a historical point of view and these are contrasted with more recent alternative approaches. Conclusions are reached regarding possible future developments.
K Bowden; N V Harris; C A Watson
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Journal of chemotherapy (Florence, Italy)     Volume:  5     ISSN:  1120-009X     ISO Abbreviation:  J Chemother     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-06-30     Completed Date:  1994-06-30     Revised Date:  2009-08-04    
Medline Journal Info:
Nlm Unique ID:  8907348     Medline TA:  J Chemother     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  377-88     Citation Subset:  IM    
Department of Chemistry & Biological Chemistry, University of Essex, Colchester, U.K.
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MeSH Terms
Anti-Infective Agents / pharmacology*
Folic Acid Antagonists*
Pteridines / pharmacology
Pyrimidines / pharmacology
Structure-Activity Relationship
Reg. No./Substance:
0/Anti-Infective Agents; 0/Folic Acid Antagonists; 0/Pteridines; 0/Pyrimidines

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