Document Detail


Structure-activity relationships of dihydrofolate reductase inhibitors.
MedLine Citation:
PMID:  8195829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Structure-activity relationships of antibacterial dihydrofolate reductase inhibitors are reviewed. A short introduction is followed by a more detailed review of developments since 1980. The design of site directed inhibitors based on data from X-ray crystallographic, NMR spectroscopy and molecular graphic studies is discussed. The development of quantitative structure-activity relations is surveyed from a historical point of view and these are contrasted with more recent alternative approaches. Conclusions are reached regarding possible future developments.
Authors:
K Bowden; N V Harris; C A Watson
Related Documents :
9307009 - Comparative anatomy of the aldo-keto reductase superfamily.
1510969 - Complementary perturbation of the kinetic mechanism and catalytic effectiveness of dihy...
8126439 - Insertion of transposon tn5 into a structural gene of the membrane-bound nitrate reduct...
20462199 - Two distinct mechanisms of inactivation of the class ic ribonucleotide reductase from c...
16552139 - Structure determination of an fmn reductase from pseudomonas aeruginosa pa01 using sulf...
10731419 - The crystal structure of dihydrofolate reductase from thermotoga maritima: molecular fe...
18191399 - Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophen...
22528499 - Highly sensitive quenched fluorescent substrate of legionella major secretory protein (...
9342349 - Identification of active sites in amidase: evolutionary relationship between amide bond...
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Journal of chemotherapy (Florence, Italy)     Volume:  5     ISSN:  1120-009X     ISO Abbreviation:  J Chemother     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-06-30     Completed Date:  1994-06-30     Revised Date:  2009-08-04    
Medline Journal Info:
Nlm Unique ID:  8907348     Medline TA:  J Chemother     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  377-88     Citation Subset:  IM    
Affiliation:
Department of Chemistry & Biological Chemistry, University of Essex, Colchester, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Infective Agents / pharmacology*
Folic Acid Antagonists*
Pteridines / pharmacology
Pyrimidines / pharmacology
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Folic Acid Antagonists; 0/Pteridines; 0/Pyrimidines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Molecular aspects and mechanism of action of dihydrofolate reductase inhibitors.
Next Document:  Basis of selectivity of antibacterial diaminopyrimidines.