Document Detail


Structure and activity relationship of monogalactosyl diacylglycerols, which selectively inhibited in vitro mammalian replicative DNA polymerase activity and human cancer cell growth.
MedLine Citation:
PMID:  19376642     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The glycoglycerolipid, monogalactosyl diacylglycerol (MGDG), containing two alpha-linolenic acids (C18:3), was isolated from bitter melon as a potent and selective inhibitor of mammalian DNA polymerase (pol) species such as pols alpha, gamma, delta, and epsilon with IC(50) values of 17.6-37.2muM. This MGDG also suppressed the growth of six human cancer cell lines, although normal human cell lines were not affected. This compound (i.e., MGDG-C18:3-C18:3) was a stronger inhibitor than both MGDG-C18:1-C18:0 and MGDG-C18:0-C18:0. In this study, we discussed the structure-function relationship in the selective inhibition of mammalian replicative pols and human cancer cell proliferation by MGDGs.
Authors:
Yuki Matsui; Takahiko Hada; Naoki Maeda; Yoshihiro Sato; Yasuhiro Yamaguchi; Toshifumi Takeuchi; Masaharu Takemura; Fumio Sugawara; Kengo Sakaguchi; Hiromi Yoshida; Yoshiyuki Mizushina
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-18
Journal Detail:
Title:  Cancer letters     Volume:  283     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-07-21     Completed Date:  2009-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  101-7     Citation Subset:  IM    
Affiliation:
Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University, Nishi-ku, Kobe, Hyogo 651-2180, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification,  pharmacology*
Cattle
Cell Line, Tumor
Cucurbitaceae / chemistry
DNA-Directed DNA Polymerase / antagonists & inhibitors,  drug effects*
Enzyme Inhibitors / chemistry,  isolation & purification,  pharmacology*
Galactolipids / chemistry,  isolation & purification,  pharmacology*
Humans
Neoplasms / enzymology*
Plant Extracts / chemistry,  isolation & purification,  pharmacology*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Enzyme Inhibitors; 0/Galactolipids; 0/Plant Extracts; 0/monogalactosyldiacylglycerol; EC 2.7.7.7/DNA-Directed DNA Polymerase

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