| Structure-activity relationship of lupane-triterpene glycosides from Acanthopanax koreanum on spleen lymphocyte IL-2 and IFN-gamma. | |
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MedLine Citation:
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PMID: 20621475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phytochemical investigation resulted in the isolation of three new lupane-triterpene glycosides acankoreosides M-O (1, 2 and 8) together with eight known lupane-triterpene glycosides (3-7, 9-11) from the leaves of Acanthopanax koreanum (Araliaceae). Their chemical structures were elucidated by mass, 1D and 2D NMR spectroscopy. The effect of eleven lupane-triterpene glycosides on Con A-induced splenolytic production of IL-2 and IFN-gamma were measured as markers of acquired immune responses. Compounds 4, 5, 7, and 11 (5, 25, and 100 microM) significantly increased IFN-gamma and IL-2 release in spleen cells. |
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Authors:
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Nguyen Xuan Nhiem; Phan Van Kiem; Chau Van Minh; Bui Huu Tai; Nguyen Huu Tung; Do Thi Ha; Kwang Su Soung; Jun Ho Kim; Ji Young Ahn; Young-Mi Lee; Young Ho Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-15 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 20 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 4927-31 Citation Subset: IM |
Copyright Information:
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Crown Copyright 2010. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acanthopanax
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chemistry* Glycosides / chemistry, isolation & purification, pharmacology Interferon-gamma / metabolism* Interleukin-2 / metabolism* Lymphocytes / drug effects, immunology Magnetic Resonance Spectroscopy Molecular Conformation Plant Leaves / chemistry Saponins / chemistry*, isolation & purification, pharmacology Spleen / cytology, immunology Structure-Activity Relationship Triterpenes / chemistry |
| Chemical | |
Reg. No./Substance:
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0/3,11,30-trihydroxylup-20(29)-en-23,28-dioic acid 28-O-(1-rhamnopyranosyl-1-4-glucopyranosyl-1-6-glucopyranosyl)ester; 0/3,19-dihydroxylup-20(29)-en-23,28-dioic acid 28-O-(1-rhamnopyranosyl-1-4-glucopyranosyl-1-6-glucopyranosyl)ester; 0/3-O-glucopyranosyl 3,11,30-trihydroxylup-20(29)-en-23,28-dioic acid 28-O-(1-rhamnopyranosyl-1-4-glucopyranosyl-1-6-glucopyranosyl)ester; 0/Glycosides; 0/Interleukin-2; 0/Saponins; 0/Triterpenes; 464-99-3/lupane; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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