Document Detail

Structure-activity relationship of bufotoxins and related compounds for the inhibition of Na+, K+ -adenosine triphosphatase.
MedLine Citation:
PMID:  3009774     Owner:  NLM     Status:  MEDLINE    
Forty kinds of bufotoxins and related compounds were tested for inhibition of Na+, K+ -adenosine triphosphatase from guinea pig heart, and the structure-activity relationship has been discussed. The inhibitory activities of bufotoxins were dependent upon the dicarboxylic acid and amino acid components. The compounds having both the arginine and suberic acid moieties showed the higher inhibitory activities. The sulfates and glucuronides of cardiac steroids exhibited much less potency than the parent genins. The mode of inhibition was determined by means of the Dixon and Lineweaver-Burk plots.
K Shimada; K Ohishi; H Fukunaga; J S Ro; T Nambara
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmacobio-dynamics     Volume:  8     ISSN:  0386-846X     ISO Abbreviation:  J. Pharmacobio-dyn.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-05-28     Completed Date:  1986-05-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7901854     Medline TA:  J Pharmacobiodyn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1054-9     Citation Subset:  IM    
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MeSH Terms
Bufanolides / pharmacology*
Chromatography, High Pressure Liquid
Guinea Pigs
Heart / drug effects
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors*
Structure-Activity Relationship
Reg. No./Substance:
0/Bufanolides; 464-81-3/bufotoxin; EC ATPase

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