Document Detail


Structure-activity relationship amongst biliary acids showing comutagenic activity towards 1,2-dimethylhydrazine.
MedLine Citation:
PMID:  6616753     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Secondary biliary acids act, in vitro, as co-mutagenic agents towards 1,2-dimethylhydrazine incubated in the presence of Salmonella typhimurium strain TA 100. The present report demonstrates an important structure-activity relationship with regard to this effect. The number and position of hydroxyl substituents, the configuration at various C atoms and the stereochemistry of the junction between rings A and B of the steroid moiety are parameters which influence the cogenotoxic activity. Beyond these structural parameters, the basic physico-chemical properties of the biliary acids could be the key factor controlling their effects. Co-incubation of the various biliary acids reveals that the so-called secondary compounds antagonise each other's activity; moreover, in the presence of a constant concentration of primary bile acids, the co-mutagenic effect is directly related to the amount of the secondary bile acids. The co-mutagenic activity of the secondary biliary acids and its modulation by their mixing could be a key factor in the etiology of colon cancer.
Authors:
M Wilpart; P Mainguet; A Maskens; M Roberfroid
Related Documents :
15508623 - Effectiveness of cleaners and sanitizers in killing salmonella newport in the gut of a ...
21324053 - Medium ph, carbon and nitrogen concentration modulate the phosphate solubilization effi...
18676183 - Amyloid-beta detection with saccharide immobilized gold nanoparticle on carbon electrode.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Carcinogenesis     Volume:  4     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1239-41     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
1,2-Dimethylhydrazine
Bile Acids and Salts / pharmacology*
Chemical Phenomena
Chemistry
Deoxycholic Acid / pharmacology
Dimethylhydrazines / pharmacology*
Drug Interactions
Lithocholic Acid / pharmacology
Methylhydrazines / pharmacology*
Molecular Conformation
Mutagenicity Tests
Mutagens / pharmacology*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Dimethylhydrazines; 0/Methylhydrazines; 0/Mutagens; 434-13-9/Lithocholic Acid; 540-73-8/1,2-Dimethylhydrazine; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Inhibition of initiation and promotion by N-methylnitrosourea-induced colon carcinogenesis in rats b...
Next Document:  The in vivo tissue disposition and in vitro target-tissue metabolism of the tobacco-specific carcino...