Document Detail

Structure-activity relationship amongst biliary acids showing comutagenic activity towards 1,2-dimethylhydrazine.
MedLine Citation:
PMID:  6616753     Owner:  NLM     Status:  MEDLINE    
Secondary biliary acids act, in vitro, as co-mutagenic agents towards 1,2-dimethylhydrazine incubated in the presence of Salmonella typhimurium strain TA 100. The present report demonstrates an important structure-activity relationship with regard to this effect. The number and position of hydroxyl substituents, the configuration at various C atoms and the stereochemistry of the junction between rings A and B of the steroid moiety are parameters which influence the cogenotoxic activity. Beyond these structural parameters, the basic physico-chemical properties of the biliary acids could be the key factor controlling their effects. Co-incubation of the various biliary acids reveals that the so-called secondary compounds antagonise each other's activity; moreover, in the presence of a constant concentration of primary bile acids, the co-mutagenic effect is directly related to the amount of the secondary bile acids. The co-mutagenic activity of the secondary biliary acids and its modulation by their mixing could be a key factor in the etiology of colon cancer.
M Wilpart; P Mainguet; A Maskens; M Roberfroid
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Carcinogenesis     Volume:  4     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1239-41     Citation Subset:  IM    
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MeSH Terms
Bile Acids and Salts / pharmacology*
Chemical Phenomena
Deoxycholic Acid / pharmacology
Dimethylhydrazines / pharmacology*
Drug Interactions
Lithocholic Acid / pharmacology
Methylhydrazines / pharmacology*
Molecular Conformation
Mutagenicity Tests
Mutagens / pharmacology*
Structure-Activity Relationship
Reg. No./Substance:
0/Bile Acids and Salts; 0/Dimethylhydrazines; 0/Methylhydrazines; 0/Mutagens; 434-13-9/Lithocholic Acid; 540-73-8/1,2-Dimethylhydrazine; 83-44-3/Deoxycholic Acid

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