| Structure-activity relationship amongst biliary acids showing comutagenic activity towards 1,2-dimethylhydrazine. | |
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MedLine Citation:
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PMID: 6616753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Secondary biliary acids act, in vitro, as co-mutagenic agents towards 1,2-dimethylhydrazine incubated in the presence of Salmonella typhimurium strain TA 100. The present report demonstrates an important structure-activity relationship with regard to this effect. The number and position of hydroxyl substituents, the configuration at various C atoms and the stereochemistry of the junction between rings A and B of the steroid moiety are parameters which influence the cogenotoxic activity. Beyond these structural parameters, the basic physico-chemical properties of the biliary acids could be the key factor controlling their effects. Co-incubation of the various biliary acids reveals that the so-called secondary compounds antagonise each other's activity; moreover, in the presence of a constant concentration of primary bile acids, the co-mutagenic effect is directly related to the amount of the secondary bile acids. The co-mutagenic activity of the secondary biliary acids and its modulation by their mixing could be a key factor in the etiology of colon cancer. |
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Authors:
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M Wilpart; P Mainguet; A Maskens; M Roberfroid |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Carcinogenesis Volume: 4 ISSN: 0143-3334 ISO Abbreviation: Carcinogenesis Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1239-41 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1,2-Dimethylhydrazine Bile Acids and Salts / pharmacology* Chemical Phenomena Chemistry Deoxycholic Acid / pharmacology Dimethylhydrazines / pharmacology* Drug Interactions Lithocholic Acid / pharmacology Methylhydrazines / pharmacology* Molecular Conformation Mutagenicity Tests Mutagens / pharmacology* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Dimethylhydrazines; 0/Methylhydrazines; 0/Mutagens; 434-13-9/Lithocholic Acid; 540-73-8/1,2-Dimethylhydrazine; 83-44-3/Deoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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