| Structure-activity relation of thyroid hormone analogues and tissue epidermal growth factor concentrations in neonatal and adult mice. | |
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MedLine Citation:
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PMID: 6608265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have shown a positive correlation between the epidermal growth factor concentration in neonatal mouse skin and prior treatment with thyroxine (T4) or triiodothyronine (T3). The results of the present study indicate similar activity of other levorotatory iodothyronine analogues and suggest the following scale of decreasing potency: T3, triiodothyroacetic acid, triiodothyropropionic acid, T4, reverse T3, and diiodothyronine. Metabolically inactive analogues (reverse T3, diiodothyronine) have no effect on skin EGF levels. A similar response pattern was observed in the adult, female mouse submandibular gland, except that T4 seemed relatively more effective. |
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Authors:
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S B Hoath; J Lakshmanan; D A Fisher |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of diseases of children (1960) Volume: 138 ISSN: 0002-922X ISO Abbreviation: Am. J. Dis. Child. Publication Date: 1984 Mar |
Date Detail:
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Created Date: 1984-03-30 Completed Date: 1984-03-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370471 Medline TA: Am J Dis Child Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 251-3 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Epidermal Growth Factor / analysis* Female Humans Infant, Newborn Mice Pregnancy Skin / analysis* Structure-Activity Relationship Thyroxine / pharmacology* Triiodothyronine / analogs & derivatives, pharmacology* |
| Chemical | |
Reg. No./Substance:
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51-24-1/3,3',5-triiodothyroacetic acid; 51-26-3/3,3',5-triiodothyropropionic acid; 62229-50-9/Epidermal Growth Factor; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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