Document Detail


Structure-activity relation of thyroid hormone analogues and tissue epidermal growth factor concentrations in neonatal and adult mice.
MedLine Citation:
PMID:  6608265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have shown a positive correlation between the epidermal growth factor concentration in neonatal mouse skin and prior treatment with thyroxine (T4) or triiodothyronine (T3). The results of the present study indicate similar activity of other levorotatory iodothyronine analogues and suggest the following scale of decreasing potency: T3, triiodothyroacetic acid, triiodothyropropionic acid, T4, reverse T3, and diiodothyronine. Metabolically inactive analogues (reverse T3, diiodothyronine) have no effect on skin EGF levels. A similar response pattern was observed in the adult, female mouse submandibular gland, except that T4 seemed relatively more effective.
Authors:
S B Hoath; J Lakshmanan; D A Fisher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  138     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-03-30     Completed Date:  1984-03-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  251-3     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Epidermal Growth Factor / analysis*
Female
Humans
Infant, Newborn
Mice
Pregnancy
Skin / analysis*
Structure-Activity Relationship
Thyroxine / pharmacology*
Triiodothyronine / analogs & derivatives,  pharmacology*
Chemical
Reg. No./Substance:
51-24-1/3,3',5-triiodothyroacetic acid; 51-26-3/3,3',5-triiodothyropropionic acid; 62229-50-9/Epidermal Growth Factor; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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