Document Detail

Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees.
MedLine Citation:
PMID:  7765503     Owner:  NLM     Status:  MEDLINE    
Nine peptides to inhibit angiotensin I converting enzyme (ACE) were isolated from sake and sake lees. They were short peptides with 5 or fewer amino acid residues, and many of them had a tryptophan or tyrosine residue at the C-terminus. We synthesized the peptide fragments of IYPRY and YGGY, and measured their inhibitory activity. As a result, we have concluded that hydrophobic amino acids in the sequence and amino acid at C-terminus had an important role in the inhibition. When digested with pepsin and pancreatin, YGGY lost its inhibitory activity but IYPRY maintained its activity. YGGY and IYPRY were orally administered to spontaneously hypertensive rats (SHR) at the dose of 100 mg/kg. YGGY didn't change the blood pressure of SHR, but IYPRY reduced their blood pressure. The hypotensive effect of IYPRY continued for 30 h after administration. Also, three dipeptides among the IYPRY fragments, IY, YP and RY, had hypotensive effects, and the effect of RY continued for 30 h after administration.
Y Saito; K Wanezaki; A Kawato; S Imayasu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  58     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-01-05     Completed Date:  1995-01-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1767-71     Citation Subset:  B    
Research Institute, Gekkeikan Sake Co., Ltd., Kyoto, Japan.
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MeSH Terms
Amino Acid Sequence
Angiotensin-Converting Enzyme Inhibitors / chemistry,  isolation & purification*,  pharmacology*
Blood Pressure / drug effects
Molecular Sequence Data
Oligopeptides / chemistry,  isolation & purification*,  pharmacology*
Rats, Inbred SHR
Structure-Activity Relationship
Tryptophan / analysis
Wine / analysis*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Oligopeptides; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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