Document Detail

Structure of acinetoferrin, a new citrate-based dihydroxamate siderophore from Acinetobacter haemolyticus.
MedLine Citation:
PMID:  8148619     Owner:  NLM     Status:  MEDLINE    
From low-iron cultures of Acinetobacter haemolyticus ATCC 17906, a new hydroxamate siderophore was purified by XAD-7 adsorption followed by preparative thin layer chromatography. The siderophore, named acinetoferrin, released citric acid, 1,3-diaminopropane and (E)-2-octenoic acid upon hydrolysis with HCl, reductive hydrolysis with HI and oxidation with periodate, respectively. Structure elucidation by a combination of NMR spectroscopy and positive fast atom bombardment mass spectrometry revealed that acinetoferrin is a derivative of citric acid, both of its terminal carboxyl groups being symmetrically amide-linked with the 1-amino-3-(N-hydroxy-N-2-octenylamino)propane residues. The (E)-2-octenoic acid is novel as a component of the siderophores.
N Okujo; Y Sakakibara; T Yoshida; S Yamamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine     Volume:  7     ISSN:  0966-0844     ISO Abbreviation:  Biometals     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-05-09     Completed Date:  1994-05-09     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  9208478     Medline TA:  Biometals     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  170-6     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
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MeSH Terms
Acinetobacter / chemistry*,  growth & development,  metabolism
Citrates / analysis
Citric Acid
Culture Media
Hydroxamic Acids / chemistry*,  isolation & purification,  metabolism
Iron / metabolism
Magnetic Resonance Spectroscopy
Molecular Structure
Siderophores / biosynthesis,  chemistry*,  isolation & purification
Spectrometry, Mass, Fast Atom Bombardment
Tricarboxylic Acids / chemistry*,  isolation & purification,  metabolism
Reg. No./Substance:
0/Citrates; 0/Culture Media; 0/Hydroxamic Acids; 0/Siderophores; 0/Tricarboxylic Acids; 0/acinetoferrin; 7439-89-6/Iron; 77-92-9/Citric Acid

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