| Structure-Function Relationships of the Antibacterial Activity of Phenolic Acids and Their Metabolism by Lactic Acid Bacteria. | |
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MedLine Citation:
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PMID: 21895894 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: To determine structure-function relationships of antibacterial phenolic acids and their metabolites produced by lactic acid bacteria (LAB). Methods and Results: Minimum inhibitory concentrations (MICs) of 6 hydroxybenzoic and 6 hydroxycinnamic acids were determined with Lactobacillus plantarum, L. hammesii, Escherichia coli, and Bacillus subtilis as indicator strains. The antibacterial activity of phenolic acids increased at lower pH. A decreasing number of hydroxyl groups enhanced activity of hydroxybenzoic acids, but had minor effects on hydroxycinnamic acids. Substitution of hydroxyl groups with methoxy groups increased activity of hydroxybenzoic, but not of hydroxycinnamic acids. Metabolism of chlorogenic, caffeic, p-coumaric, ferulic, protocatechuic, or p-hydroxybenzoic acids by L. plantarum, L. hammesii, L. fermentum and L. reuteri was analysed by LC-DAD-MS. Furthermore, MICs of substrates and metabolites were compared. Decarboxylated and/or reduced metabolites of phenolic acids had a lower activity than the substrates. Strain-specific metabolism of phenolic acids generally corresponded to resistance. Conclusions: The influence of lipophilicity on the antibacterial activity of hydroxybenzoic acids is stronger than that of hydroxycinnamic acids. Metabolism of phenolic acids by LAB detoxifies phenolic acids. |
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Authors:
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Alma F Sánchez-Maldonado; Andreas Schieber; Michael G Gänzle |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-3 |
Journal Detail:
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Title: Journal of applied microbiology Volume: - ISSN: 1365-2672 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706280 Medline TA: J Appl Microbiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 The Society for Applied Microbiology. |
Affiliation:
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Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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