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Structure-Function Relationship between FDF, FDT, SAP and Scanning Laser Ophthalmoscopy in Glaucoma Patients.
MedLine Citation:
PMID:  23074201     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: FLICKER DEFINED FORM PERIMETRY (FDF) AND FREQUENCY DOUBLING TECHNOLOGY PERIMETRY (FDT) ARE ALLEGED TO DETECT GLAUCOMA AT AN EARLIER STAGE THAN STANDARD AUTOMATED PERIMETRY (SAP). IT IS THE PURPOSE OF THIS STUDY TO INVESTIGATE THE STRUCTURE-FUNCTION RELATIONSHIP BETWEEN FDF, FDT, SAP, AND CONFOCAL SCANNING LASER OPHTHALMOSCOPY (CSLO) IN PATIENTS WITH GLAUCOMA. METHODS: Seventy-six patients with glaucoma were included in the study. Patients were tested with SAP, Matrix-FDT, FDF perimetry and cSLO. Structure-function relationships between global and sectoral cSLO parameters and global and sectoral mean sensitivity (MS) of SAP, Matrix-FDT and FDF were calculated using Spearman's rank correlation and linear regression. RESULTS: Overall, Flicker Defined Form perimetry showed the strongest structure-function relationship (global correlation with rim area: 0.44; range of significant sectoral FDF values: 0.23 to 0.69), followed by Frequency Doubling Technology (global correlation with rim area: 0.35; range of significant sectoral FDT values: 0.25 to 0.60). Standard Automated Perimetry presented with the weakest structure-function relationship and fewer statistically significant results (global correlation with rim volume: 0.32; range of significant sectoral SAP values: 0.23 to 0.58). Sector-by-sector, the structure-function relationship was greatest in the supero-temporal and infero-temporal regions. Weakest correlations were found in the infero-nasal and nasal sectors. CONCLUSIONS: The correlation between structure and function is stronger in FDF and FDT compared to SAP. Correlations are strongest in temporal areas where glaucomatous damage tends to occur first. A better understanding of the structure-function relationship should allow for improved detection and management of glaucoma patients.
Authors:
Julia Lamparter; Richard A Russell; Andreas Schulze; Ann-Christin Schuff; Norbert Pfeiffer; Esther M Hoffmann
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-16
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  -     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
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