Document Detail

Structure-function relationship of the macular visual field sensitivity and the ganglion cell complex thickness in glaucoma.
MedLine Citation:
PMID:  22700706     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We attempted to understand better the relationship between the macular visual field (VF) mean sensitivity (MS) assessed by standard automated perimetry (SAP) and the ganglion cell complex thickness (GCCT), and macular peripapillary retinal nerve fiber layer thickness (mpRNFLT) assessed by spectral domain optical coherence tomography (SD-OCT, RTVue-100) in open-angle glaucoma (OAG) patients.
METHODS: We enrolled in the study 217 OAG patients with baseline intraocular pressure (IOP) in the statistically normal range. GCCT and mpRNFLT measurements, using the ganglion cell complex (GCC) and the optic nerve head (ONH) modes of RTVue-100 OCT, were obtained for analysis. Macular VF sensitivity was recorded in the dB and 1/L scales. The relationship of the function (MS) and structure (GCCT, mpRNFLT) was sought globally and in two VF sectors (superior and inferior).
RESULTS: The relationship of the macular VF sensitivity (dB) to the GCC, and mpRNFL global (R(2) = 0.111, 0.127) and sectoral (superior R(2) = 0.358, 0.171; inferior R(2) = 0.227, 0.263) thicknesses were statistically significant (all P < 0.05). The relationship of the macular VF sensitivity to the GCCT differed significantly from that of the macular VF sensitivity to the mpRNFL in the superior VF sector (R(2) = 0.358 vs. 0.171, P < 0.05).
CONCLUSIONS: GCCT determined by SD-OCT (RTVue-100) showed a statistically significant structure-function association with macular VF, and the strength of the association was greater than that of the mpRNFL with macular VF in the superior central VF area.
Jung Hwa Na; Michael S Kook; Youngrok Lee; Seunghee Baek
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Publication Detail:
Type:  Journal Article     Date:  2012-07-31
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  53     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-01     Completed Date:  2012-10-15     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5044-51     Citation Subset:  IM    
Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, Korea.
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MeSH Terms
Cross-Sectional Studies
Glaucoma / physiopathology*
Macula Lutea
Middle Aged
Nerve Fibers / pathology
Retinal Ganglion Cells / pathology*
Tomography, Optical Coherence
Visual Fields / physiology*

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