Document Detail


The Structure of the Eukaryotic Ribosome at 3.0 A Resolution.
MedLine Citation:
PMID:  22096102     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Ribosomes translate genetic information encoded by mRNA into proteins. Many aspects of translation and its regulation are specific to eukaryotes whose ribosomes are much larger and intricate than their bacterial counterparts. Here, we report the crystal structure of the 80S ribosome from the yeast Saccharomyces cerevisiae at 3.0 Å resolution that includes nearly all ribosomal RNA bases and protein side chains as well as an additional protein Stm1. This atomic model reveals the architecture of eukaryote-specific elements and their interaction with the universally conserved core, and describes all eukaryote-specific bridges between the two ribosomal subunits. It forms the structural framework for the design and analysis of experiments that explore the eukaryotic translation apparatus and the evolutionary forces that shaped it.
Authors:
Adam Ben-Shem; Nicolas Garreau de Loubresse; Sergey Melnikov; Lasse Jenner; Gulnara Yusupova; Marat Yusupov
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-17
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  -     ISSN:  1095-9203     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries, BP10142, Illkirch F-67400, France; INSERM, U964, Illkirch F-67400, France; CNRS, UMR7104, Illkirch F-67400, France; and Université de Strasbourg, Strasbourg F-67000, France.
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