| Structure-Based Design of a Highly Constrained Nucleic Acid Analogue: Improved Duplex Stabilization by Restricting Sugar Pucker and Torsion Angle γ | |
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MedLine Citation:
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PMID: 22915274 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Dual conformational restriction: A new, highly constrained modification of the α-L-locked nucleic acid (α-L-LNA) scaffold that locks the sugar furanose ring in an N-type configuration and also restricts rotation around torsion angle γ was synthesized. This new modification increases the thermostability of an oligonucleotide duplex compared to using a single mode of constraint alone. |
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Authors:
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Stephen Hanessian; Benjamin R Schroeder; Robert D Giacometti; Bradley L Merner; Michael Ostergaard; Eric E Swayze; Punit P Seth |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-22 |
Journal Detail:
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Title: Angewandte Chemie (International ed. in English) Volume: - ISSN: 1521-3773 ISO Abbreviation: Angew. Chem. Int. Ed. Engl. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370543 Medline TA: Angew Chem Int Ed Engl Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Chemistry, Université de Montréal, C.P. 6128, Succ. Centre-ville, Montréal, QC H3C 3J7 (Canada). stephen.hanessian@umontreal.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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