| Structure based design of 11β-HSD1 inhibitors. | |
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MedLine Citation:
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PMID: 20809895 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Controlling elevated tissue-specific levels of cortisol may provide a novel therapeutic approach for treating metabolic syndrome. This concept has spurred large scale medicinal chemistry efforts in the pharmaceutical industry for the design of 11β-HSD1 inhibitors. High resolution X-ray crystal structures of inhibitors in complex with the enzyme have facilitated the structure-based design of diverse classes of molecules. A summary of binding modes, trends in structure-activity relationships, and the pharmacodynamic data of inhibitors from each class is presented. |
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Authors:
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Suresh Singh; Colin Tice |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current pharmaceutical biotechnology Volume: 11 ISSN: 1873-4316 ISO Abbreviation: Curr Pharm Biotechnol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960530 Medline TA: Curr Pharm Biotechnol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 779-91 Citation Subset: IM |
Affiliation:
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Vitae Pharmaceuticals, 502 W. Office Center Drive, Fort Washington, PA 19034, USA. ssingh@vitaerx.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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