Document Detail


Structural variation in the alleles of a short tandem repeat system at the human alpha fibrinogen locus.
MedLine Citation:
PMID:  8652421     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper reports the sequences of 22 alleles identified at the HumFGA (human alpha fibrinogen) short tandem repeat locus in the British Caucasian and Afro-Caribbean populations. Alleles at the lower end of the observed size range were found to increase in size by 4-bp increments with the repeat unit following the pattern TC(TCTT)n. However, 5 alleles were identified that differed in size by 2 bp from the 4 bp increment as a result of the deletion of a TC dinucleotide, or the addition of a TT dinucleotide, immediately prior to the 1st repeat unit. Alleles at the upper end of the observed size range were found to have a more complex repeat unit structure and also exhibited duplication of both 5' and 3' flanking sequences. A nomenclature for the designation of HumFGA alleles is proposed on the basis of this sequence data.
Authors:
M D Barber; B J McKeown; B H Parkin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of legal medicine     Volume:  108     ISSN:  0937-9827     ISO Abbreviation:  Int. J. Legal Med.     Publication Date:  1996  
Date Detail:
Created Date:  1996-07-30     Completed Date:  1996-07-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9101456     Medline TA:  Int J Legal Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  180-5     Citation Subset:  IM    
Affiliation:
Metropolitan Police Forensic Science Laboratory, London, UK.
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group / genetics
Base Sequence
Chromosomes, Human, Pair 4
DNA Fingerprinting*
European Continental Ancestry Group / genetics
Humans
Information Systems
London
Molecular Sequence Data
Polymerase Chain Reaction
Repetitive Sequences, Nucleic Acid*
Terminology as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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