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Structural vaccinology starts to deliver.
MedLine Citation:
PMID:  23154260     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Following the impact of the genomics revolution on vaccine research and the development of reverse vaccinology, it was predicted that another new approach, structure-based antigen design, would become a driving force for vaccine innovation. Now, 5 years on, there are several examples of how structure-based design, or structural vaccinology, can deliver new vaccine antigens that were not possible before. Here, we discuss some of these examples and the contribution of structural vaccinology to our understanding of the protective epitopes of important bacterial and viral pathogens.
Authors:
Philip R Dormitzer; Guido Grandi; Rino Rappuoli
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature reviews. Microbiology     Volume:  10     ISSN:  1740-1534     ISO Abbreviation:  Nat. Rev. Microbiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101190261     Medline TA:  Nat Rev Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  807-13     Citation Subset:  IM    
Affiliation:
Novartis Vaccines and Diagnostics Inc., 350 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
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