| Structural specificity in ether lipid biosynthesis. Formation of hydroxyalkyl and oxoalkyl glycerophosphatides. | |
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MedLine Citation:
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PMID: 1150644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Structural specificity of alkyl glycerolipid formation was studied in myelinating rat brain. 1,2-[2-14-C,2-3-H]Heptadecanediol, 1,2-[1-14-C]octadecanediol, and 1-O-2-hydroxy-[1-14-C]heptadecyl-rac-glycerol were administered intracerebrally and their incorporation into phospholipids was determined after time periods ranging from 6 to 48 hours. Experimental evidence is presented to support the following conclusions. (a) Long chain 1,2-alkanediols serve as direct precursors of the 2-hydroxyalkyl moieties of both choline and ethanolamine glycerophosphatides. (b) 1,2-Alkanediols are oxidized to 1-hydroxy-2alkanones which serve as precursors of the 2-oxoalkyl moieties of the glycerophosphatides. (c) Oxidations of hydroxy groups and reductions of oxo groups do not occur at the phospholipids, but are confined to 1,2-alkanediols and 1-hydroxy-2-alkanones, respectively. (d) Metabolic degradation of 1,2-alkanediols proceeds by oxidation to the corresponding 2-hydroxy and/or 2-oxo fatty acids and decarboxylation. |
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Authors:
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Chang N-C; H H Schmid |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 250 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 1975 Jul |
Date Detail:
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Created Date: 1975-11-06 Completed Date: 1975-11-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4877-82 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism* Carbon Radioisotopes Fatty Alcohols / metabolism Glycerides / metabolism Glycols / metabolism Male Palmitic Acids / metabolism Phosphatidylcholines / metabolism Phosphatidylethanolamines / metabolism Phospholipids / biosynthesis* Rats Tritium |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Fatty Alcohols; 0/Glycerides; 0/Glycols; 0/Palmitic Acids; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phospholipids; 10028-17-8/Tritium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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