Document Detail

Structural and rheological characterization of hyaluronic acid-based scaffolds for adipose tissue engineering.
MedLine Citation:
PMID:  17602736     Owner:  NLM     Status:  MEDLINE    
In this study the attention has been focused on the ester derivative of hyaluronic acid (HA), HYAFF11, as a potential three-dimensional scaffold in adipose tissue engineering. Different HYAFF11 sponges having different pore sizes, coated or not coated with HA, have been studied from a rheological and morphological point of view in order to correlate their structure to the macroscopic and degradation properties both in vitro and in vivo, using rat model. The in vitro results indicate that the HYAFF11 sponges possess proper structural and mechanical properties to be used as scaffolds for adipose tissue engineering and, among all the analysed samples, uncoated HYAFF11 large-pore sponges showed a longer lasting mechanical stability. From the in vivo results, it was observed that the elastic modulus of scaffolds seeded with preadipocytes, the biohybrid constructs, and explanted after 3 months of implantation in autologous rat model are over one order of magnitude higher than the corresponding values for the native tissue. These results could suggest that the implanted scaffolds can be invaded and populated by different cells, not only adipocytes, that can produce new matrix having different properties from that of adipose tissue.
Assunta Borzacchiello; Laura Mayol; Piera A Ramires; Andrea Pastorello; Chiara Di Bartolo; Luigi Ambrosio; Evelina Milella
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-28
Journal Detail:
Title:  Biomaterials     Volume:  28     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-13     Completed Date:  2007-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  4399-408     Citation Subset:  IM    
IMCB-CNR, P.le Tecchio 80, 80125 Naples, Italy.
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MeSH Terms
Adipocytes / cytology*,  metabolism,  transplantation
Biodegradation, Environmental
Cell Adhesion
Cell Culture Techniques
Cells, Cultured
Coated Materials, Biocompatible / chemistry*
Hyaluronic Acid / analogs & derivatives,  chemistry*
Implants, Experimental
Materials Testing
Microscopy, Electron, Scanning
Time Factors
Tissue Engineering / methods*
Transplantation, Homologous
Reg. No./Substance:
0/Coated Materials, Biocompatible; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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