Document Detail


Structural requirements of peptide YY for biological activity at enteric sites.
MedLine Citation:
PMID:  1443144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peptide YY (PYY) is a colonic hormone consisting of 36 amino acids that is a potent inhibitor of pancreatic exocrine, gastric acid, and insulin secretion. The objective of the present experiments was to characterize the structural requirements of PYY for inhibition of pancreatic exocrine, gastric acid, and insulin secretion, using conscious dogs prepared with gastric and pancreatic fistulas. Intravenous administration of PYY-(1-36), PYY-(3-36), or PYY-(4-36) (400 pmol.kg-1 x h-1) inhibited cholecystokinin-8-stimulated (25 pmol.kg-1 x h-1) pancreatic exocrine secretion (P < 0.05); however, PYY-(1-10), PYY-(1-20), PYY-(6-36), PYY-(10-36), PYY-(13-36), PYY-(24-36), and PYY-(27-36) did not inhibit pancreatic exocrine secretion. Intravenous administration of PYY-(1-36), PYY-(3-36), or PYY-(4-36) (200, 400, 800 pmol.kg-1 x h-1) inhibited pentagastrin (0.5 microgram.kg-1 x h-1)-stimulated gastric acid secretion (P < 0.05), as well as 2-deoxy-D-glucose-stimulated insulin release (75 mg/kg) in a dose-related manner. PYY-(6-36), PYY-(13-36), and [Leu31, Pro34] neuropeptide Y did not inhibit either gastric acid secretion or insulin release. In the gastric acid and insulin secretion bioassays, PYY-(1-36) was significantly more potent than PYY-(3-36) and PYY-(4-36); however, in the pancreatic exocrine secretion bioassay, the inhibitory effects of PYY-(3-36) and PYY-(1-36) did not differ significantly. PYY-(4-36) was less potent than PYY-(1-36) on pancreatic exocrine secretion.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
K Yoshinaga; T Mochizuki; N Yanaihara; K Oshima; M Izukura; M Kogire; S Sumi; G Gomez; T Uchida; J C Thompson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  263     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-23     Completed Date:  1992-12-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G695-701     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Texas Medical Branch, Galveston 77555.
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MeSH Terms
Descriptor/Qualifier:
Animals
Deoxyglucose / pharmacology
Dogs
Female
Gastric Acid / secretion
Half-Life
Insulin / secretion
Male
Pancreas / secretion
Pentagastrin / pharmacology
Peptide Fragments / pharmacology
Peptide YY
Peptides / chemistry,  pharmacology,  physiology*
Sincalide / pharmacology
Grant Support
ID/Acronym/Agency:
DK-35608/DK/NIDDK NIH HHS; DK-37406/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/Peptides; 106388-42-5/Peptide YY; 11061-68-0/Insulin; 154-17-6/Deoxyglucose; 154-58-5/1,5-anhydroglucitol; 25126-32-3/Sincalide; 5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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