Document Detail


Structural remodeling in the limb circulation: impact of obesity and diabetes.
MedLine Citation:
PMID:  17613804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity is an emerging epidemic worldwide and threatens cardiovascular health due to the complications of accompanying metabolic dysfunction. One potential mechanism by which these complications are advanced is structural alteration in the microcirculation perfusing target organs. In this brief review, the authors focus on the structural adaptations that occur in the microcirculation, with specific focus on changes in basement membrane thickness and vascular structure. By delineating changes in end-stage disease and recent insights from animal studies, they hope to convince the reader (1) that diabetic disease in the limb is associated with profound changes in arteriolar structure and (2) that parallel changes in microvascular architecture precede the onset of frank type II diabetes.
Authors:
David W Stepp; Eric J Belin De Chantemele
Related Documents :
16026364 - Increased plasma markers of inflammation and endothelial dysfunction and their associat...
23056354 - Increasing blood glucose variability is a precursor of sepsis and mortality in burned p...
23061304 - Prevalence of factors predisposing to foot complication and their relation to other risks.
20062734 - Diabetic myonecrosis in a patient with hepatic cirrhosis: a case report and review of t...
15102614 - Nonexercise activity thermogenesis (neat): environment and biology.
908474 - Plasma glucagon suppression by phenformin in man.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  14     ISSN:  1073-9688     ISO Abbreviation:  Microcirculation     Publication Date:    2007 Jun-Jul
Date Detail:
Created Date:  2007-07-06     Completed Date:  2007-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-6     Citation Subset:  IM    
Affiliation:
Vascular Biology Center and Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA. dsteep@mail.mcg.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus / physiopathology*
Endothelium, Vascular / pathology,  physiopathology
Extremities / blood supply
Humans
Microcirculation / pathology,  physiopathology
Obesity / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Obesity, insulin resistance, and capillary recruitment.
Next Document:  Mechanisms of coronary dysfunction in obesity and insulin resistance.