Document Detail

Structural remodeling in the limb circulation: impact of obesity and diabetes.
MedLine Citation:
PMID:  17613804     Owner:  NLM     Status:  MEDLINE    
Obesity is an emerging epidemic worldwide and threatens cardiovascular health due to the complications of accompanying metabolic dysfunction. One potential mechanism by which these complications are advanced is structural alteration in the microcirculation perfusing target organs. In this brief review, the authors focus on the structural adaptations that occur in the microcirculation, with specific focus on changes in basement membrane thickness and vascular structure. By delineating changes in end-stage disease and recent insights from animal studies, they hope to convince the reader (1) that diabetic disease in the limb is associated with profound changes in arteriolar structure and (2) that parallel changes in microvascular architecture precede the onset of frank type II diabetes.
David W Stepp; Eric J Belin De Chantemele
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  14     ISSN:  1073-9688     ISO Abbreviation:  Microcirculation     Publication Date:    2007 Jun-Jul
Date Detail:
Created Date:  2007-07-06     Completed Date:  2007-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-6     Citation Subset:  IM    
Vascular Biology Center and Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA.
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MeSH Terms
Diabetes Mellitus / physiopathology*
Endothelium, Vascular / pathology,  physiopathology
Extremities / blood supply
Microcirculation / pathology,  physiopathology
Obesity / physiopathology*

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