Document Detail

Structural profile of cardiac myxoma.
MedLine Citation:
PMID:  6205669     Owner:  NLM     Status:  MEDLINE    
In the 10-year period 1972-1981, 35 cardiac myxomas from 34 patients were studied. 29 tumors were surgical specimens and 6 were necropsy observations. No patient was under 10 years and only 3 were in the second decade. 25 growths were located in the left atrium, 6 in the right atrium and 2 in the right ventricle; 1 patient presented with myxomas involving both atria. The surface examined in 31 tumors appeared villous in 15, smooth in 13 and slightly irregular in 3. The tumor cells were enmeshed in Alcian blue positive mucoid material and presented as isolated, aggregated in clusters or in small cords, or lining vascular-like spaces. Ultrastructural examination performed in 9 cases disclosed a few features of endothelial cells: microvilli, cell interdigitations, desmosomes and pinocytotic vesicles; cytoplasmic organelles were usually more numerous in the cells arranged in clusters and lining spaces than in those isolated or in small cords; well-developed Golgi complex and endoplasmic reticulum were frequently observed and suggest a secretory function for the myxoma cells. The findings herein reported together with those of recent cytochemical studies support a mesenchymal origin for the myxoma cells with differentiation to endothelial line.
M Valente
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied pathology     Volume:  1     ISSN:  0252-1172     ISO Abbreviation:  Appl Pathol     Publication Date:  1983  
Date Detail:
Created Date:  1984-10-02     Completed Date:  1984-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308921     Medline TA:  Appl Pathol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  251-63     Citation Subset:  IM    
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MeSH Terms
Cytoskeleton / ultrastructure
Desmosomes / ultrastructure
Endoplasmic Reticulum / ultrastructure
Endothelium / pathology
Golgi Apparatus / ultrastructure
Heart Atria / ultrastructure
Heart Neoplasms / ultrastructure*
Heart Ventricles / ultrastructure
Microscopy, Electron
Microvilli / ultrastructure
Middle Aged
Myxoma / ultrastructure*
Staining and Labeling

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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