| Structural and physiological responses to prolonged constant lighting in the cone-rich retina of Arvicanthis ansorgei. | |
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MedLine Citation:
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PMID: 20950611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cone photoreceptor death is a leading cause of blindness in industrialised countries. Despite this, there are few mammalian models available to study cone pathophysiology. The diurnal rodent Arvicanthis possesses a high cone percentage and ease of maintenance. We recently described the effect of ambient light conditions on cyclic disc shedding, and observed that 24 h of constant illumination ("LL") completely disrupted the normal rhythmic process and increased cone shedding fourfold. The current study was undertaken to see whether protracted constant illumination (7 days LL) would further perturb cone (and rod) turnover, and possibly lead to photoreceptor degeneration. Whereas control (cyclic lighting) retinas exhibited a typical early morning burst in phagosomes, LL retinas exhibited only low uniform numbers of rod and cone phagosomes across 24 h, with no peak of shedding at any time. Morphometric and immunohistochemical analyses of Arvicanthis retinas after 7 days LL (300 lux) showed no structural changes compared to control retinas. |
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Authors:
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Madah Khawn-i-Muhammad Mehdi; David Hicks |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-13 |
Journal Detail:
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Title: Experimental eye research Volume: 91 ISSN: 1096-0007 ISO Abbreviation: Exp. Eye Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370707 Medline TA: Exp Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 793-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Département de Neurobiologie des Rythmes, CNRS UPR 3212 Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Count Circadian Rhythm / radiation effects* Disease Models, Animal* Down-Regulation Fluorescent Antibody Technique, Indirect Light* Muridae Opsins / metabolism Phagocytosis / radiation effects Phagosomes / physiology Radiation Injuries, Experimental / metabolism*, physiopathology Retinal Cone Photoreceptor Cells / pathology, radiation effects* Retinal Degeneration / metabolism*, physiopathology Retinal Pigment Epithelium / metabolism*, pathology Retinal Rod Photoreceptor Cells / pathology, radiation effects |
| Chemical | |
Reg. No./Substance:
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0/Opsins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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