| Structural perspective of peptidoglycan biosynthesis and assembly. | |
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MedLine Citation:
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PMID: 22663080 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The peptidoglycan biosynthetic pathway is a critical process in the bacterial cell and is exploited as a target for the design of antibiotics. This pathway culminates in the production of the peptidoglycan layer, which is composed of polymerized glycan chains with cross-linked peptide substituents. This layer forms the major structural component of the protective barrier known as the cell wall. Disruption in the assembly of the peptidoglycan layer causes a weakened cell wall and subsequent bacterial lysis. With bacteria responsible for both properly functioning human health (probiotic strains) and potentially serious illness (pathogenic strains), a delicate balance is necessary during clinical intervention. Recent research has furthered our understanding of the precise molecular structures, mechanisms of action, and functional interactions involved in peptidoglycan biosynthesis. This research is helping guide our understanding of how to capitalize on peptidoglycan-based therapeutics and, at a more fundamental level, of the complex machinery that creates this critical barrier for bacterial survival. |
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Authors:
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Andrew L Lovering; Susan S Safadi; Natalie C J Strynadka |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annual review of biochemistry Volume: 81 ISSN: 1545-4509 ISO Abbreviation: Annu. Rev. Biochem. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985150R Medline TA: Annu Rev Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 451-78 Citation Subset: IM |
Affiliation:
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School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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