Document Detail

Structural microengineers: pathogenic Escherichia coli redesigns the actin cytoskeleton in host cells.
MedLine Citation:
PMID:  19141278     Owner:  NLM     Status:  MEDLINE    
Several virulent bacteria have the ability to manipulate the host cell actin cytoskeleton as part of their pathogenic strategy. These pathogens subvert the host cell actin polymerization machinery for various purposes including motility within host cells, cell-to-cell spread, and to prevent phagocytic engulfment by professional phagocytes. In contrast to intracellular pathogens, pathogenic Escherichia coli (including both enterohemorrhagic and enteropathogenic E. coli) subvert actin polymerization from an extracellular position to facilitate adherence. This review summarizes recent data on the mechanisms by which pathogenic E. coli hijack members of the Wiskott-Aldrich syndrome protein family to manipulate actin polymerization within host cells, including the novel, and surprisingly simple, mechanism recently revealed for the EspFu effector.
Neta Sal-Man; Esther Biemans-Oldehinkel; B Brett Finlay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Structure (London, England : 1993)     Volume:  17     ISSN:  0969-2126     ISO Abbreviation:  Structure     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-14     Completed Date:  2009-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101087697     Medline TA:  Structure     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  IM    
Michael Smith Laboratories, The University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
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MeSH Terms
Actins / chemistry*
Biopolymers / chemistry*
Cytoskeleton / chemistry*
Escherichia coli / physiology*
Grant Support
//Howard Hughes Medical Institute
Reg. No./Substance:
0/Actins; 0/Biopolymers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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