Document Detail

Structural and mechanical factors influencing infarct scar collagen organization.
MedLine Citation:
PMID:  10644599     Owner:  NLM     Status:  MEDLINE    
Although large collagen fibers in myocardial infarct scar are highly organized, little is known about mechanisms controlling this organization. The preexisting extracellular matrix may act as a scaffold along which fibroblasts migrate. Conversely, deformation within the ischemic area could guide fibroblasts so new collagen is oriented to counteract the stretch. To investigate these potential mechanisms, we infarcted three groups of pigs. Group 1 served as infarct controls. Group 2 had the endocardium slit longitudinally to alter local systolic deformation. Group 3 had a plug sectioned from ischemic tissue and rotated 90 degrees. The slit altered systolic deformation in the infarcted tissue, changing circumferential strain from expansion to compression and increasing radial strain and shears and the variability of collagen fiber angles but not the mean angle. In the plug pigs, when deformation, matrix orientation, and continuity are altered in the infarct area, the result is complete disarray in the organization of collagen within the infarct scar.
S D Zimmerman; W J Karlon; J W Holmes; J H Omens; J W Covell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  278     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-06-07     Completed Date:  2000-06-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H194-200     Citation Subset:  IM    
Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA.
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MeSH Terms
Cicatrix / etiology*,  pathology,  physiopathology*
Collagen / physiology*
Myocardial Infarction / complications*,  physiopathology
Stress, Mechanical
Reg. No./Substance:

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