Document Detail


Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.
MedLine Citation:
PMID:  23046130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human immunodeficiency virus-1 (HIV-1) envelope protein (Env) and influenza hemagglutinin (HA) are the surface glycoproteins responsible for viral entry into host cells, the first step in the virus life cycle necessary to initiate infection. These glycoproteins exhibit a high degree of sequence variability and glycosylation, which are used as strategies to escape host immune responses. Nonetheless, antibodies with broadly neutralizing activity against these viruses have been isolated that have managed to overcome these barriers. Here, we review recent advances in the structural characterization of these antibodies with their viral antigens that defines a few sites of vulnerability on these viral spikes. These broadly neutralizing antibodies tend to focus their recognition on the sites of similar function between the two viruses: the receptor-binding site and membrane fusion machinery. However, some sites of recognition are unique to the virus neutralized, such as the dense shield of oligomannose carbohydrates on HIV-1 Env. These observations are discussed in the context of structure-based design strategies to aid in vaccine design or development of antivirals.
Authors:
Jean-Philippe Julien; Peter S Lee; Ian A Wilson
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  250     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-02-25     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  180-98     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Department of Molecular Biology, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
AIDS Vaccines / chemistry,  immunology
Antibodies, Neutralizing / chemistry*,  immunology,  pharmacology
Antigenic Variation
Gene Products, env / antagonists & inhibitors,  chemistry*,  immunology
HIV Antibodies / chemistry*,  immunology,  pharmacology
HIV-1 / drug effects,  immunology
Hemagglutinin Glycoproteins, Influenza Virus / chemistry*,  immunology,  metabolism
Humans
Influenza A virus / drug effects,  immunology
Influenza Vaccines / chemistry,  immunology
Models, Molecular
Receptors, Virus / antagonists & inhibitors*,  immunology
Species Specificity
Structural Homology, Protein
Virus Internalization / drug effects
Grant Support
ID/Acronym/Agency:
AI84817/AI/NIAID NIH HHS; GM080209/GM/NIGMS NIH HHS; R01 AI084817/AI/NIAID NIH HHS; T32 GM080209/GM/NIGMS NIH HHS; //Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/AIDS Vaccines; 0/Antibodies, Neutralizing; 0/Gene Products, env; 0/HIV Antibodies; 0/Hemagglutinin Glycoproteins, Influenza Virus; 0/Influenza Vaccines; 0/Receptors, Virus; 0/hemagglutinin, human influenza A virus
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