Document Detail


Structural insights into activation of antiviral NK cell responses.
MedLine Citation:
PMID:  23046134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Natural killer (NK) cells are key components of innate immune responses, providing surveillance against cells undergoing tumorigenesis or infection, by viruses or internal pathogens. NK cells can directly eliminate compromised cells and regulate downstream responses of the innate and acquired immune systems through the release of immune modulators (cytokines, interferons). The importance of the role NK cells play in immune defense was demonstrated originally in herpes viral infections, usually mild or localized, which become severe and life threatening in NK-deficient patients . NK cell effector functions are governed by balancing opposing signals from a diverse array of activating and inhibitory receptors. Many NK receptors occur in paired activating and inhibitory isoforms and recognize major histocompatibility complex (MHC) class I proteins with varying degrees of peptide specificity. Structural studies have made considerable inroads into understanding the molecular mechanisms employed to broadly recognize multiple MHC ligands or specific pathogen-associated antigens and the strategies employed by viruses to thwart these defenses. Although many details of NK development, signaling, and integration remain mysterious, it is clear that NK receptors are key components of a system exquisitely tuned to sense any dysregulation in MHC class I expression, or the expression of certain viral antigens, resulting in the elimination of affected cells.
Authors:
Kathryn A Finton; Roland K Strong
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  250     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-02-25     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  239-57     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
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MeSH Terms
Descriptor/Qualifier:
Antigens, Viral / chemistry*,  genetics,  immunology
Cytokines / immunology
Gene Expression
Histocompatibility Antigens Class I / chemistry*,  genetics,  immunology
Humans
Immune Evasion
Immunity, Innate
Killer Cells, Natural / immunology*,  virology
Models, Molecular
Protein Binding
Receptors, Natural Killer Cell / chemistry*,  genetics,  immunology
Signal Transduction
T-Cell Antigen Receptor Specificity
Virus Diseases / immunology*,  virology
Viruses / immunology*
Grant Support
ID/Acronym/Agency:
P01 AI094419/AI/NIAID NIH HHS; P01 AI94419/AI/NIAID NIH HHS; R01 AI048675/AI/NIAID NIH HHS; R01 AI48675/AI/NIAID NIH HHS; T32 GM008268/GM/NIGMS NIH HHS; T32 GM08268/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Viral; 0/Cytokines; 0/Histocompatibility Antigens Class I; 0/Receptors, Natural Killer Cell
Comments/Corrections

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