| Structural insights into activation of antiviral NK cell responses. | |
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MedLine Citation:
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PMID: 23046134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Natural killer (NK) cells are key components of innate immune responses, providing surveillance against cells undergoing tumorigenesis or infection, by viruses or internal pathogens. NK cells can directly eliminate compromised cells and regulate downstream responses of the innate and acquired immune systems through the release of immune modulators (cytokines, interferons). The importance of the role NK cells play in immune defense was demonstrated originally in herpes viral infections, usually mild or localized, which become severe and life threatening in NK-deficient patients . NK cell effector functions are governed by balancing opposing signals from a diverse array of activating and inhibitory receptors. Many NK receptors occur in paired activating and inhibitory isoforms and recognize major histocompatibility complex (MHC) class I proteins with varying degrees of peptide specificity. Structural studies have made considerable inroads into understanding the molecular mechanisms employed to broadly recognize multiple MHC ligands or specific pathogen-associated antigens and the strategies employed by viruses to thwart these defenses. Although many details of NK development, signaling, and integration remain mysterious, it is clear that NK receptors are key components of a system exquisitely tuned to sense any dysregulation in MHC class I expression, or the expression of certain viral antigens, resulting in the elimination of affected cells. |
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Authors:
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Kathryn A Finton; Roland K Strong |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Immunological reviews Volume: 250 ISSN: 1600-065X ISO Abbreviation: Immunol. Rev. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-10 Completed Date: 2013-02-25 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: England |
Other Details:
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Languages: eng Pagination: 239-57 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Viral
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chemistry*,
genetics,
immunology Cytokines / immunology Gene Expression Histocompatibility Antigens Class I / chemistry*, genetics, immunology Humans Immune Evasion Immunity, Innate Killer Cells, Natural / immunology*, virology Models, Molecular Protein Binding Receptors, Natural Killer Cell / chemistry*, genetics, immunology Signal Transduction T-Cell Antigen Receptor Specificity Virus Diseases / immunology*, virology Viruses / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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P01 AI094419/AI/NIAID NIH HHS; P01 AI94419/AI/NIAID NIH HHS; R01 AI048675/AI/NIAID NIH HHS; R01 AI48675/AI/NIAID NIH HHS; T32 GM008268/GM/NIGMS NIH HHS; T32 GM08268/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Viral; 0/Cytokines; 0/Histocompatibility Antigens Class I; 0/Receptors, Natural Killer Cell |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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