Document Detail


Structural insights into ABC transporter mechanism.
MedLine Citation:
PMID:  18948194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ATP-binding cassette (ABC) transporters utilize the energy from ATP hydrolysis to transport substances across the membrane. In recent years, crystal structures of several ABC transporters have become available. These structures show that both importers and exporters oscillate between two conformations: an inward-facing conformation with the substrate translocation pathway open to the cytoplasm and an outward-facing conformation with the translocation pathway facing the opposite side of the membrane. In this review, conformational differences found in the structures of homologous ABC transporters are analyzed to understand how alternating-access is achieved. It appears that rigid-body rotations of the transmembrane subunits, coinciding with the opening and closing of the nucleotide-binding subunits, couples ATP hydrolysis to substrate translocation.
Authors:
Michael L Oldham; Amy L Davidson; Jue Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-11-05
Journal Detail:
Title:  Current opinion in structural biology     Volume:  18     ISSN:  1879-033X     ISO Abbreviation:  Curr. Opin. Struct. Biol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-08     Completed Date:  2009-02-17     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  9107784     Medline TA:  Curr Opin Struct Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  726-33     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN 47907, USA. mloldham@purdue.edu
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MeSH Terms
Descriptor/Qualifier:
ATP-Binding Cassette Transporters / chemistry*,  metabolism*
Animals
Binding Sites
Crystallography
Membrane Transport Proteins / chemistry,  metabolism
Protein Binding
Protein Conformation
Protein Structure, Tertiary
Grant Support
ID/Acronym/Agency:
GM070515/GM/NIGMS NIH HHS; GM49261/GM/NIGMS NIH HHS; R01 GM049261-13/GM/NIGMS NIH HHS; R01 GM070515-05/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/ATP-Binding Cassette Transporters; 0/Membrane Transport Proteins
Comments/Corrections

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