| Structural and histomorphometric studies of iliac crest trabecular and cortical bone in autosomal dominant osteopetrosis: a study of two radiological types. | |
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MedLine Citation:
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PMID: 2660883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cylindrical iliac crest biopsies were obtained from 16 patients with autosomal dominant osteopetrosis after intravital double labeling with tetracycline, and compared with normal age- and sex-matched controls. Ten patients had the radiological type I (5 women, 5 men, aged 17-62 years, mean 42) characterized by diffuse, symmetrical osteosclerosis and enlarged thickness of the cranial vault. Six patients had type II (2 women, 4 men, aged 22-44 years, mean 36), where "Rugger Jersey Spine" and endobone are characteristic findings. Structural studies of cortical and trabecular bone were performed, and trabecular bone resorption and formation rates were studied using dynamic histomorphometry. The total biopsy length (C. Wi) were increased in type I (p less than 0.05), and unchanged in type II. Both types showed increased cortical width (Ct. Wi) (p less than 0.01 and p less than 0.05, respectively), and decreased fractional width of cancellous bone (Cn.Wi/C.Wi) (p less than 0.01 and p less than 0.05). The fractional trabecular bone volume (BV/TV) and trabecular thickness (Tb. Th) were both significantly increased in type I (p less than 0.05), while resorptive and formative indices of trabecular bone remodeling were normal. No difference was found in trabecular bone balance, which was slightly positive in both patients and controls. In type II osteopetrosis the eroded surfaces (OS/BS) were significantly increased (p less than 0.01), as was the total resorptive period RP) (p less than 0.05). The resorption depth (R.D.) was normal, while the resorption rate (MRR) was insignificantly decreased. Many big multinucleated osteoclasts were seen in this type suggesting defective resorptive function.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J Bollerslev; T Steiniche; F Melsen; L Mosekilde |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bone Volume: 10 ISSN: 8756-3282 ISO Abbreviation: Bone Publication Date: 1989 |
Date Detail:
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Created Date: 1989-07-28 Completed Date: 1989-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8504048 Medline TA: Bone Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 19-24 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Svendborg Hospital, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biopsy Bone Resorption Female Histological Techniques Humans Ilium / pathology*, radiography Male Middle Aged Osteogenesis Osteopetrosis / pathology*, physiopathology, radiography Tetracycline / diagnostic use |
| Chemical | |
Reg. No./Substance:
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60-54-8/Tetracycline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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