Document Detail


Structural, functional, and molecular characterization of the SHHF model of heart failure.
MedLine Citation:
PMID:  12384454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart failure is a complex multifactorial disease resulting in a myriad of progressive changes at the molecular, cellular, and physiological level. To better understand the mechanisms associated with the development of congestive heart failure, a comprehensive examination of the aging lean male spontaneously hypertensive, heart failure-prone rat (SHHF) was conducted. Myocardial function and structural integrity progressively diminished as evidenced by decreased ejection fraction and increased left ventricular volume measured using echocardiography. Functional and structural changes were accompanied by elevations in circulating inflammatory markers, including tumor necrosis factor-alpha (TNF-alpha), IL-6, and TNF receptors type 1 and 2. Increased systemic inflammatory marker levels were consistent with age-dependent changes in the expression pattern of genes that contribute to stress, inflammation, and the extracellular matrix in SHHF animals analyzed from age 4 to 18 mo. In summary, the SHHF rat shares many hallmark features of the human disease state and represents a key experimental model for the dissection of complex human heart failure pathophysiology.
Authors:
Jonathan R R Heyen; Eileen R Blasi; Kristen Nikula; Ricardo Rocha; Heather A Daust; Gregory Frierdich; John F Van Vleet; Pam De Ciechi; Ellen G McMahon; Amy E Rudolph
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  283     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-17     Completed Date:  2002-11-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1775-84     Citation Subset:  IM    
Affiliation:
Pharmacia Corporation, 800 N. Lindbergh Boulevard, St. Louis, MO 63167, USA. Jonathan.R.Heyen@PHARMACIA.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers
Cytokines / genetics
Disease Models, Animal*
Echocardiography
Extracellular Matrix Proteins / genetics
Gene Expression
Heart Failure / pathology,  physiopathology*,  ultrasonography
Immunohistochemistry
Male
Myocardium / chemistry,  pathology
Rats
Rats, Mutant Strains*
Stroke Volume
Transcription, Genetic
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/Extracellular Matrix Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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