| Structural and functional diversity of the lectin repertoire in teleost fish: Relevance to innate and adaptive immunity. | |
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MedLine Citation:
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PMID: 21896283 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Protein-carbohydrate interactions mediated by lectins have been recognized as key components of innate immunity in vertebrates and invertebrates, not only for recognition of potential pathogens, but also for participating in downstream effector functions, such as their agglutination, immobilization, and complement-mediated opsonization and killing. More recently, lectins have been identified as critical regulators of mammalian adaptive immune responses. Fish are endowed with virtually all components of the mammalian adaptive immunity, and are equipped with a complex lectin repertoire. In this review, we discuss evidence suggesting that: (a) lectin repertoires in teleost fish are highly diversified, and include not only representatives of the lectin families described in mammals, but also members of lectin families described for the first time in fish species; (b) the tissue-specific expression and localization of the diverse lectin repertoires and their molecular partners is consistent with their distinct biological roles in innate and adaptive immunity; (c) although some lectins may bind endogenous ligands, others bind sugars on the surface of potential pathogens; (d) in addition to pathogen recognition and opsonization, some lectins display additional effector roles, such as complement activation and regulation of immune functions; and (e) some lectins that recognize exogenous ligands mediate processes unrelated to immunity: they may act as anti-freeze proteins or prevent polyspermia during fertilization. |
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Authors:
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Gerardo R Vasta; Mihai Nita-Lazar; Barbara Giomarelli; Hafiz Ahmed; Shaojun Du; Matteo Cammarata; Nicolò Parrinello; Mario A Bianchet; L Mario Amzel |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-30 |
Journal Detail:
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Title: Developmental and comparative immunology Volume: - ISSN: 1879-0089 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708205 Medline TA: Dev Comp Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Department of Microbiology and Immunology, University of Maryland School of Medicine, Program in the Biology of Model Systems, UMB, IMET, 701 East Pratt Street, Baltimore, MD 21202, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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