Document Detail


Structural-functional correlations between hippocampal volume and cortico-limbic emotional responses in depressed children.
MedLine Citation:
PMID:  23055092     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although hippocampal atrophy and altered functional brain responses to emotional stimuli have been found in major depressive disorder (MDD), the relationship between the two is not yet well understood. The present study focused on children with and without a history of preschool onset MDD (PO-MDD) and directly examined the relations between hippocampal volume and functional brain activation to affect-eliciting stimuli. Children completed annual diagnostic assessments starting at preschool. When children were school-aged, high-resolution structural MRI and task-related functional MRI data were acquired from N = 64 nonmedicated children. During fMRI, subjects were shown emotional faces. Results from the total sample indicated that smaller bilateral hippocampal volumes were associated with greater cortico-limbic (e.g., amygdala, hippocampus, dorsolateral prefrontal cortex) activation to sad or negative faces versus neutral faces. Left hippocampal volume was negatively associated with the cortico-limbic activation in both the PO-MDD and healthy children. Right hippocampal volume was negatively correlated with amygdala responses in the PO-MDD group, but not in the healthy comparison group. These findings suggest that there may be important interrelationships between reduced hippocampal volume and hyperactivation of brain responses in children, both those with and those without a history of PO-MDD.
Authors:
Hideo Suzuki; Kelly N Botteron; Joan L Luby; Andy C Belden; Michael S Gaffrey; Casey M Babb; Tomoyuki Nishino; Michael I Miller; J Tilak Ratnanather; Deanna M Barch
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cognitive, affective & behavioral neuroscience     Volume:  13     ISSN:  1531-135X     ISO Abbreviation:  Cogn Affect Behav Neurosci     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-07-19     Revised Date:  2014-03-09    
Medline Journal Info:
Nlm Unique ID:  101083946     Medline TA:  Cogn Affect Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cerebral Cortex / pathology*,  physiopathology
Child
Child, Preschool
Depressive Disorder, Major / pathology*,  physiopathology
Emotions / physiology*
Facial Expression
Female
Hippocampus / pathology*,  physiopathology
Humans
Image Processing, Computer-Assisted
Longitudinal Studies
Magnetic Resonance Imaging
Male
Neural Pathways / pathology,  physiopathology
Organ Size
Photic Stimulation
Grant Support
ID/Acronym/Agency:
K01 MH090515/MH/NIMH NIH HHS; P41 EB015909/EB/NIBIB NIH HHS; P41-EB015909/EB/NIBIB NIH HHS; R01 EB008171/EB/NIBIB NIH HHS; R01 MH064769/MH/NIMH NIH HHS; R01 MH090786/MH/NIMH NIH HHS; R01-EB008171/EB/NIBIB NIH HHS; R01-MH090786/MH/NIMH NIH HHS; R01-MH64769/MH/NIMH NIH HHS
Comments/Corrections

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