Document Detail

Structural and functional arterial properties in patients with obstructive sleep apnoea syndrome and cardiovascular comorbidities.
MedLine Citation:
PMID:  18075519     Owner:  NLM     Status:  MEDLINE    
The increased severity of obstructive sleep apnoea syndrome (OSAS) is associated with a parallel increase in the incidence of cardiovascular events. Whether the increased severity of OSAS is in fact associated with impaired arterial properties has never been thoroughly studied. In patients with OSAS who carry a high burden of cardiovascular risk factors, we investigated whether the severity of OSAS is associated with deterioration in the arterial properties, independent of classical cardiovascular risk factors. In 74 consecutive patients with OSAS, we non-invasively assessed, by means of tonometry and high-resolution ultrasound: carotid intima-media thickness (IMT), carotid diameter and plaques, carotid-femoral pulse wave velocity (PWV), central augmentation index (AI) and central blood pressures. The respiratory disturbance index was an independent predictor of IMT and PWV but not of carotid plaques, carotid diameter, AI or central blood pressures. Several parameters of nocturnal hypoxaemia were independently correlated with carotid IMT and PWV. In conclusion, arterial stiffening and thickening are modulated by the severity of OSAS, independently from age and cardiovascular risk factors.
A D Protogerou; J-P Laaban; S Czernichow; C Kostopoulos; J Lekakis; M E Safar; J Blacher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-13
Journal Detail:
Title:  Journal of human hypertension     Volume:  22     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-15     Completed Date:  2008-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  415-22     Citation Subset:  IM    
Diagnostic Center, Hôtel-Dieu Hospital, Paris, France.
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MeSH Terms
Aorta / physiopathology
Cardiovascular Diseases / etiology*
Carotid Arteries / pathology*,  physiopathology
Femoral Artery / physiopathology*
Middle Aged
Multivariate Analysis
Risk Factors
Sleep Apnea, Obstructive / complications,  pathology*,  physiopathology*
Tunica Intima / pathology
Tunica Media / pathology
Comment In:
J Hum Hypertens. 2008 Jun;22(6):377-9   [PMID:  18385745 ]

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