Document Detail

Structural and functional adaptation to hypoxia in the rat brain.
MedLine Citation:
PMID:  15299038     Owner:  NLM     Status:  MEDLINE    
Chronic exposure to a hypoxic environment leads to structural and functional adaptations in the rat brain. One significant adaptation is a decrease in intercapillary distances through a near doubling of the capillary density, which begins after about 1 week of hypoxic exposure and is completed by 3 weeks. Hypoxic angiogenesis is controlled by activation of downstream genes by Hypoxia Inducible Factor-1 and Angiopoietin-2. The processes that increase capillary density are reversible upon restoration of the ambient oxygen concentration. Capillary regression, which also occurs over a 3-week period, is accomplished through activation of apoptosis. The implication from these observations is that the brain naturally functions in a low, but controlled, oxygen environment. Acute imbalances in oxygen delivery and metabolic demand are addressed through changes in blood flow; persistent imbalances activate mechanisms that adjust capillary density. The mechanisms that control these processes decline with age.
Joseph C LaManna; Juan Carlos Chavez; Paola Pichiule
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  207     ISSN:  0022-0949     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-09     Completed Date:  2004-12-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3163-9     Citation Subset:  IM    
Departments of Neurology and Anatomy, Case Medical School, Cleveland, OH 44106, USA.
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MeSH Terms
Adaptation, Physiological*
Age Factors
Anoxia / metabolism,  physiopathology*
Apoptosis / physiology*
Brain / blood supply*,  metabolism
Capillaries / physiology
Gene Expression Regulation
Models, Biological*
Neovascularization, Pathologic / metabolism*
Oxygen / metabolism
Rats / metabolism*
Regional Blood Flow
Grant Support
Reg. No./Substance:

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