Document Detail

Structural features and mechanisms for sensing high osmolarity in microorganisms.
MedLine Citation:
PMID:  15063855     Owner:  NLM     Status:  MEDLINE    
During their lifetime, most organisms experience osmotic stress, mostly due to fluctuating external osmolarities, but also as a result of desiccation or freezing. Under these conditions, the ratio of osmolytes to water and macromolecules in the cells is significantly altered. To survive, cells must continuously sense these alterations and adapt accordingly. Osmolarity is a physico-chemical parameter that causes pleiotropic alterations in cell physiology. Recent research has revealed various mechanisms to sense high external osmolarity, based on monitoring cellular changes that are associated with the altered environment.
Ralf Heermann; Kirsten Jung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in microbiology     Volume:  7     ISSN:  1369-5274     ISO Abbreviation:  Curr. Opin. Microbiol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-05     Completed Date:  2004-06-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9815056     Medline TA:  Curr Opin Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  168-74     Citation Subset:  IM    
TU Darmstadt, Institute for Microbiology and Genetics, Schnittspahnstrasse10, D-64287 Darmstadt, Germany.
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MeSH Terms
Bacterial Physiological Phenomena*
Bacterial Proteins / chemistry,  physiology*
Osmotic Pressure
Water-Electrolyte Balance / physiology*
Reg. No./Substance:
0/Bacterial Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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