| Structural evidence that endothelial cell growth factor beta is the precursor of both endothelial cell growth factor alpha and acidic fibroblast growth factor. | |
| | |
MedLine Citation:
|
PMID: 3532107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Two endothelial cell growth factors (ECGF) have been purified from bovine brain and termed alpha- and beta-ECGF [Burgess, W. H., Mehlman, T., Friesel, R., Johnson, W. V. & Maciag, T. (1985) J. Biol. Chem. 260, 11389-11392]. Amino acid sequence analysis indicates that beta-ECGF represents a 20 amino acid amino-terminal extension of alpha-ECGF and a 14 amino acid amino-terminal extension of acidic fibroblast growth factor. These data indicate that both alpha-ECGF and acidic fibroblast growth factor may be derived from beta-ECGF by posttranslational processing. Analysis of the amino-terminal 14 residues of beta-ECGF by fast-atom-bombardment mass spectrometry established the amino acid sequence of this region and the identity of the blocking group at the amino terminus (acetyl). |
| | |
Authors:
|
W H Burgess; T Mehlman; D R Marshak; B A Fraser; T Maciag |
Related Documents
:
|
2043677 - Enzymatic reaction of beta-n-methylaminoalanine with l-amino acid oxidase. 6548507 - Synthesis of the putative metabolites of plant sterols: (24r)- and (24s)-24-methyl-5 be... 8740577 - 4-pentafluoroethylumbelliferyl-beta-d-glucoside as a new fluorogenic substrate for acid... 18600547 - Beta-alanine and beta-aminoisobutyric acid levels in two siblings with dihydropyrimidin... 2054387 - The nucleotide sequence of rabbit liver transferrin cdna. 6318707 - Identification and quantitation of arachidonic-acid metabolic products in rabbit, rat a... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 83 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1986 Oct |
Date Detail:
|
Created Date: 1986-10-30 Completed Date: 1986-10-30 Revised Date: 2010-09-09 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 7216-20 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Sequence Animals Cattle Cyanogen Bromide Endothelial Growth Factors Fibroblast Growth Factors Growth Substances* / genetics Mass Spectrometry Peptide Fragments / analysis Protein Precursors Thermolysin Trypsin |
| Grant Support | |
ID/Acronym/Agency:
|
AG04807/AG/NIA NIH HHS; HL310765/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Endothelial Growth Factors; 0/Growth Substances; 0/Peptide Fragments; 0/Protein Precursors; 506-68-3/Cyanogen Bromide; 62031-54-3/Fibroblast Growth Factors; EC 3.4.21.4/Trypsin; EC 3.4.24.27/Thermolysin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Isolation of an episomal yeast gene and replication origin as chromatin.
Next Document: A cell surface desmosome-associated component: identification of tissue-specific cell adhesion molec...