| Structural effect of cationic copolymers on nucleic acid-chaperoning activity. | |
| | |
MedLine Citation:
|
PMID: 17150800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In order to evaluate the effect of cationic copolymer structures on their nucleic acid-chaperoning activity, we prepared various copolymers having different cationic residues or backbone molecular weight. It was revealed that nucleic acid-chaperoning activity increases with increasing molecular weight of the copolymer backbone and that the copolymer having the guanidino groups is effective for increasing nucleic acid-chaperoning activity. Compared with PLL-g-Dex, GPLL-g-Dex has weak activity to stabilize ds DNA. This weak stabilization effect of GPLL-g-Dex may contribute to the higher accelerating effect. |
| | |
Authors:
|
Kaoru Takada; Sung Won Choi; Asako Yamayoshi; Arihiro Kano; Atsushi Maruyama |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nucleic acids symposium series (2004) Volume: - ISSN: 1746-8272 ISO Abbreviation: Nucleic Acids Symp Ser (Oxf) Publication Date: 2006 |
Date Detail:
|
Created Date: 2006-12-07 Completed Date: 2007-08-17 Revised Date: 2007-09-19 |
Medline Journal Info:
|
Nlm Unique ID: 101259965 Medline TA: Nucleic Acids Symp Ser (Oxf) Country: England |
Other Details:
|
Languages: eng Pagination: 27-8 Citation Subset: IM |
Affiliation:
|
Institute for Materials Chemistry and Engineering, Kyushu University, 6-10-1 Hakozaki, Fukuoka 812-8581, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
DNA
/
chemistry* Dextrans / chemistry* Molecular Chaperones / chemistry* Polylysine / analogs & derivatives*, chemistry Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
|
0/Molecular Chaperones; 0/poly(lysine)-graft-dextran; 0/polylysine-graft-poly(N(epsilon)-amidinolysine)-graft-dextran; 25104-18-1/Polylysine; 9004-54-0/Dextrans; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Structure analysis of oligonucleotide in organic solvent.
Next Document: Synthesis of synthetic small molecule transcription factors (STF).