| Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study. | |
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MedLine Citation:
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PMID: 12724248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is growing evidence that schizophrenia is a disorder of cortical connectivity. Specifically, frontotemporal and frontoparietal connections are thought to be functionally impaired. Diffusion tensor magnetic resonance imaging (DT-MRI) is a technique that has the potential to demonstrate structural disconnectivity in schizophrenia. AIMS: To investigate the structural integrity of frontotemporal and frontoparietal white matter tracts in schizophrenia. METHOD: Thirty patients with DSM-IV schizophrenia and thirty matched control subjects underwent DT-MRI and structural MRI. Fractional anisotropy - an index of the integrity of white matter tracts - was determined in the uncinate fasciculus, the anterior cingulum and the arcuate fasciculus and analysed using voxel-based morphometry. RESULTS: There was reduced fractional anisotropy in the left uncinate fasciculus and left arcuate fasciculus in patients with schizophrenia compared with controls. CONCLUSIONS: The findings of reduced white matter tract integrity in the left uncinate fasciculus and left arcuate fasciculus suggest that there is frontotemporal and frontoparietal structural disconnectivity in schizophrenia. |
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Authors:
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J Burns; D Job; M E Bastin; H Whalley; T Macgillivray; E C Johnstone; S M Lawrie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of psychiatry : the journal of mental science Volume: 182 ISSN: 0007-1250 ISO Abbreviation: Br J Psychiatry Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-01 Completed Date: 2003-06-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0342367 Medline TA: Br J Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 439-43 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, UK. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Anisotropy Brain Mapping / methods Case-Control Studies Cerebral Cortex / pathology* Humans Magnetic Resonance Imaging / methods*, statistics & numerical data Neural Pathways / pathology* Schizophrenia / pathology* |
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