Document Detail

Structural and chemical characterization of inorganic deposits in calcified human mitral valve.
MedLine Citation:
PMID:  3199134     Owner:  NLM     Status:  MEDLINE    
X-ray diffraction, i.r. absorption, and chemical analyses have been carried out on the mineral deposits of calcified human mitral valves and glutaraldehyde-preserved porcine aortic grafts. The mineral deposits isolated from highly calcified mitral valves and porcine aortic grafts are constituted of type B-carbonate apatite. Magnesium substituted beta-tricalcium phosphate is present, together with an apatitic phase similar to dahllite, in the ashes of poorly calcified mitral valves. The contraction of the unit cell of beta-tricalcium phosphate due to magnesium incorporation is compared with the variation of the lattice constants of synthetic beta-tricalcium phosphate at different degree of magnesium substitution for calcium. The results reveal the important role of magnesium on the calcification of human valves. In fact, the apatitic phase deposited at the beginning of the calcification process, when there is a high magnesium content, converts completely into beta-tricalcium phosphate by heat treatment at 1,000 degrees C. On the other hand, when the calcification becomes massive, magnesium content appears highly reduced, and the deposited apatitic phase is characterized by a high thermal stability.
A Bigi; L Compostella; A M Fichera; E Foresti; M Gazzano; A Ripamonti; N Roveri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of inorganic biochemistry     Volume:  34     ISSN:  0162-0134     ISO Abbreviation:  J. Inorg. Biochem.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-01-26     Completed Date:  1989-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905788     Medline TA:  J Inorg Biochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-82     Citation Subset:  IM    
Dipartimento di Chimica G. Ciamician, Universitá di Bologna, Italy.
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MeSH Terms
Calcinosis / metabolism*
Calcium Phosphates / analysis
Cardiomyopathies / metabolism*
Heart Valve Prosthesis / adverse effects
Magnesium / analysis
Minerals / analysis*
Mitral Valve / analysis*
Reg. No./Substance:
0/Calcium Phosphates; 0/Minerals; 0/beta-tricalcium phosphate; 7439-95-4/Magnesium; 7758-87-4/tricalcium phosphate

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