Document Detail

Structural characterization of trimethylsilyl methyl glycosides derivatives by high-resolution mass spectrometry, linked scans and MIKE experiments.
MedLine Citation:
PMID:  18278584     Owner:  NLM     Status:  MEDLINE    
Gas chromatography-mass spectrometry investigations have been carried out for the structural analysis of trimethylsilyl methyl derivatives of keto-deoxy sugars and sialic acids studied under electron ionization. Fragmentation patterns were determined. The three derivatives undergo some common fragmentation pathways. Formation of fragment ions possessing cyclic resonance-stabilized structures was demonstrated. As the sialic acid derivative contained a N-acetyl substituent, some additional fragmentations occurred and were also elucidated. Thus, the mechanism of fragmentation was revealed for these derivatives and new findings concerning some series of fragment ions are presented.
Corinne Loutelier-Bourhis; Muriel Bardor; Catherine M Lange
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-17
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  390     ISSN:  1618-2650     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-20     Completed Date:  2008-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1853-60     Citation Subset:  IM    
COBRA-IRCOF, UFR des Sciences, Université de Rouen, CNRS UMR 6014, 76821, Mont-Saint-Aignan Cedex, France.
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MeSH Terms
Carbohydrate Conformation
Carbohydrates / chemistry
Gas Chromatography-Mass Spectrometry / methods*
Glycosides / analysis*
Reproducibility of Results
Sensitivity and Specificity
Sialic Acids / chemistry
Trimethylsilyl Compounds / analysis*
Reg. No./Substance:
0/Carbohydrates; 0/Glycosides; 0/Sialic Acids; 0/Trimethylsilyl Compounds

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