| Structural characterization and immunomodulating activity of a complex glucan from spores of Ganoderma lucidum. | |
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MedLine Citation:
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PMID: 11791709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A polysaccharide with a molecular weight of 1.26 x 10(5), obtained from the sporoderm-broken spores of Ganoderma lucidum, was purified by anion-exchange and gel-permeation chromatography. This polysaccharide had a strong effect on suppressing the antibody production and the Con A or LPS induced lymphocyte proliferation in mice. Chemically, the structure of the polysaccharide was identified by methylation analysis, 1 D, 2 D NMR and ESI-MS spectroscopic studies of the native one and of the oligosaccharide fragments generated by partial acid hydrolysis, Smith degradation, and acetolysis. It was concluded that the intact polysaccharide was a complex beta-D-glucan consisting of a (1-->6)-linked backbone chain, in which every other glucosyl residue was substituted at C-3 or C-4 with mono-, di- and trisaccharide branches. |
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Authors:
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X Bao; J Fang; X Li |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 65 ISSN: 0916-8451 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2002-01-15 Completed Date: 2002-07-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 2384-91 Citation Subset: IM |
Affiliation:
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Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
/
chemistry,
isolation & purification,
pharmacology Animals Antibody Formation / drug effects Carbohydrate Conformation Carbohydrate Sequence Drugs, Chinese Herbal / chemistry, isolation & purification, pharmacology Female Glucans / chemistry*, isolation & purification, pharmacology* Lymphocyte Activation / drug effects Magnetic Resonance Spectroscopy Mice Mice, Inbred ICR Molecular Sequence Data Molecular Structure Reishi / chemistry* Spores, Fungal / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Drugs, Chinese Herbal; 0/Glucans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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