Document Detail


Structural characterization and immunomodulating activity of a complex glucan from spores of Ganoderma lucidum.
MedLine Citation:
PMID:  11791709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A polysaccharide with a molecular weight of 1.26 x 10(5), obtained from the sporoderm-broken spores of Ganoderma lucidum, was purified by anion-exchange and gel-permeation chromatography. This polysaccharide had a strong effect on suppressing the antibody production and the Con A or LPS induced lymphocyte proliferation in mice. Chemically, the structure of the polysaccharide was identified by methylation analysis, 1 D, 2 D NMR and ESI-MS spectroscopic studies of the native one and of the oligosaccharide fragments generated by partial acid hydrolysis, Smith degradation, and acetolysis. It was concluded that the intact polysaccharide was a complex beta-D-glucan consisting of a (1-->6)-linked backbone chain, in which every other glucosyl residue was substituted at C-3 or C-4 with mono-, di- and trisaccharide branches.
Authors:
X Bao; J Fang; X Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  65     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2002-01-15     Completed Date:  2002-07-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2384-91     Citation Subset:  IM    
Affiliation:
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / chemistry,  isolation & purification,  pharmacology
Animals
Antibody Formation / drug effects
Carbohydrate Conformation
Carbohydrate Sequence
Drugs, Chinese Herbal / chemistry,  isolation & purification,  pharmacology
Female
Glucans / chemistry*,  isolation & purification,  pharmacology*
Lymphocyte Activation / drug effects
Magnetic Resonance Spectroscopy
Mice
Mice, Inbred ICR
Molecular Sequence Data
Molecular Structure
Reishi / chemistry*
Spores, Fungal / chemistry
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Drugs, Chinese Herbal; 0/Glucans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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