Document Detail

Structural characterization and immunomodulating activity of a complex glucan from spores of Ganoderma lucidum.
MedLine Citation:
PMID:  11791709     Owner:  NLM     Status:  MEDLINE    
A polysaccharide with a molecular weight of 1.26 x 10(5), obtained from the sporoderm-broken spores of Ganoderma lucidum, was purified by anion-exchange and gel-permeation chromatography. This polysaccharide had a strong effect on suppressing the antibody production and the Con A or LPS induced lymphocyte proliferation in mice. Chemically, the structure of the polysaccharide was identified by methylation analysis, 1 D, 2 D NMR and ESI-MS spectroscopic studies of the native one and of the oligosaccharide fragments generated by partial acid hydrolysis, Smith degradation, and acetolysis. It was concluded that the intact polysaccharide was a complex beta-D-glucan consisting of a (1-->6)-linked backbone chain, in which every other glucosyl residue was substituted at C-3 or C-4 with mono-, di- and trisaccharide branches.
X Bao; J Fang; X Li
Related Documents :
9810269 - High molecular weight acidic polysaccharides from malva sylvestris and alcea rosea.
2073639 - Structural analysis of the specific capsular polysaccharide of rhodococcus equi serotyp...
10584009 - Regulation of the feruloyl esterase (faea) gene from aspergillus niger.
2285139 - Assay for trans-p-coumaroyl esterase using a specific substrate from plant cell walls.
12475619 - Structural and compositional modifications in lignin of transgenic alfalfa down-regulat...
2208379 - Characterization of two polysaccharides having activity on the reticuloendothelial syst...
16674059 - Palladium(ii)-catalyzed asymmetric synthesis of (z)-alpha-alkylidene-gamma-butyrolactam...
9526089 - Unsaturated fatty acids as endogenous bioregulators.
9546629 - Fatty acid-binding proteins in the heart.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  65     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2002-01-15     Completed Date:  2002-07-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2384-91     Citation Subset:  IM    
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adjuvants, Immunologic / chemistry,  isolation & purification,  pharmacology
Antibody Formation / drug effects
Carbohydrate Conformation
Carbohydrate Sequence
Drugs, Chinese Herbal / chemistry,  isolation & purification,  pharmacology
Glucans / chemistry*,  isolation & purification,  pharmacology*
Lymphocyte Activation / drug effects
Magnetic Resonance Spectroscopy
Mice, Inbred ICR
Molecular Sequence Data
Molecular Structure
Reishi / chemistry*
Spores, Fungal / chemistry
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Drugs, Chinese Herbal; 0/Glucans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Antimicrobial characteristics of chitosans against food spoilage microorganisms in liquid media and ...
Next Document:  Adsorption properties and activities of lipase on a gold substrate modified by self-assembled monola...